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Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population
文献类型：期刊论文
| 作者 | Qi, Q.; Wu, Y.; Li, Huaixing（黎怀星）; Loos, R. J. F.; Hu, F. B.; Sun, Liang（孙亮）.; Lu, L.; Pan, A.; Liu, C.; Wu, H. |
| 刊名 | DIABETOLOGIA
 |
| 出版日期 | 2009 |
| 卷号 | 52期号:5页码:834-843 |
| 关键词 | Association study Chinese GCK GCKR Obesity Type 2 diabetes |
| 通讯作者 | Li, H (reprint author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | The GCKR rs780094 and GCK rs1799884 polymorphisms have been reported to be associated with dyslipidaemia and type 2 diabetes in white Europeans. The aim of this study was to replicate these associations in Han Chinese individuals and to identify the potential mechanisms underlying these associations. The single nucleotide polymorphisms rs780094 and rs1799884 were genotyped in a population-based sample of Han Chinese individuals (n = 3,210) and tested for association with risk of type 2 diabetes and related phenotypes. The GCKR rs780094 A allele was marginally associated with reduced risk of type 2 diabetes (OR 0.85, 95% CI 0.73-1.00, p value under an additive model [p ((add))] = 0.05) and significantly associated with reduced risk of impaired fasting glucose (IFG) or type 2 diabetes (OR 0.86, 95% CI 0.77-0.96, p ([add]) = 0.0032). It was also significantly associated with decreased fasting glucose and increased HOMA of beta cell function (HOMA-B) and fasting triacylglycerol levels (p ([add]) = 0.0169-5.3 x 10(-6)), but not with HOMA of insulin sensitivity (HOMA-S). The associations with type 2 diabetes and IFG remained significant after adjustment for BMI, while adjustment for HOMA-B abolished the associations. The GCKR rs780094 was also associated with obesity and BMI, independently of its association with type 2 diabetes. The GCK rs1799884 A allele was significantly associated with decreased HOMA-B (p ([add]) = 0.0005), but not with type 2 diabetes or IFG. Individuals with increasing numbers of risk alleles for both variants had significantly lower HOMA-B (p ([add]) = 5.8 x 10(-5)) in the combined analysis. Consistent with observations in white Europeans, the GCKR rs780094 polymorphism contributes to the risk of type 2 diabetes and dyslipidaemia in Han Chinese individuals. In addition, we showed that the effect on type 2 diabetes is probably mediated through impaired beta cell function rather than through obesity. |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | GLUCOKINASE REGULATORY PROTEIN ; C-REACTIVE PROTEIN ; FASTING GLUCOSE ; GENE PROMOTER ; METABOLIC-REGULATION ; TRIGLYCERIDE LEVELS ; RAT-BRAIN ; POLYMORPHISM ; MELLITUS ; RISK |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000264884100015 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/251]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Qi, Q.,Wu, Y.,Li, Huaixing,et al. Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population[J]. DIABETOLOGIA,2009,52(5):834-843. |
| APA | Qi, Q..,Wu, Y..,Li, Huaixing.,Loos, R. J. F..,Hu, F. B..,...&Lin, Xu.(2009).Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population.DIABETOLOGIA,52(5),834-843. |
| MLA | Qi, Q.,et al."Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population".DIABETOLOGIA 52.5(2009):834-843. |
入库方式： OAI收割
来源：上海营养与健康研究所
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