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Structural modulation of gut microbiota in life-long calorie-restricted mice
文献类型：期刊论文
| 作者 | Zhang, Chenhong; Li, Shoufeng; Yang, Liu（杨柳）; Huang, Ping; Li, Wenjun; Wang, Shengyue; Zhao, Guoping; Zhang, Menghui; Pang, Xiaoyan; Yan, Zhen |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2013 |
| 卷号 | 4期号:1页码:2163 |
| 通讯作者 | Zhao, LP (reprint author), Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China. |
| 英文摘要 | Calorie restriction has been regarded as the only experimental regimen that can effectively lengthen lifespan in various animal models, but the actual mechanism remains controversial. The gut microbiota has been shown to have a pivotal role in host health, and its structure is mostly shaped by diet. Here we show that life-long calorie restriction on both high-fat or low-fat diet, but not voluntary exercise, significantly changes the overall structure of the gut microbiota of C57BL/6 J mice. Calorie restriction enriches phylotypes positively correlated with lifespan, for example, the genus Lactobacillus on low-fat diet, and reduces phylotypes negatively correlated with lifespan. These calorie restriction-induced changes in the gut microbiota are concomitant with significantly reduced serum levels of lipopolysaccharide-binding protein, suggesting that animals under calorie restriction can establish a structurally balanced architecture of gut microbiota that may exert a health benefit to the host via reduction of antigen load from the gut. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | DIET-INDUCED OBESITY ; SEX-DIFFERENCES ; ENDOTOXEMIA ; MICROFLORA ; INFLAMMATION ; MECHANISM ; COMMUNITY ; HEALTH ; IMPACT ; SPAN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000323716300033 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/279]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Chenhong,Li, Shoufeng,Yang, Liu,et al. Structural modulation of gut microbiota in life-long calorie-restricted mice[J]. NATURE COMMUNICATIONS,2013,4(1):2163. |
| APA | Zhang, Chenhong.,Li, Shoufeng.,Yang, Liu.,Huang, Ping.,Li, Wenjun.,...&Zhao, Liping.(2013).Structural modulation of gut microbiota in life-long calorie-restricted mice.NATURE COMMUNICATIONS,4(1),2163. |
| MLA | Zhang, Chenhong,et al."Structural modulation of gut microbiota in life-long calorie-restricted mice".NATURE COMMUNICATIONS 4.1(2013):2163. |
入库方式： OAI收割
来源：上海营养与健康研究所
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