The Essential Role of Mbd5 in the Regulation of Somatic Growth and Glucose Homeostasis in Mice
文献类型：期刊论文
| 作者 | Du, Yarui; Liu, Bo; Guo, Fan; Xu, Guifang; Ding, Yuqiang; Liu, Yong（刘勇） ; Sun, Xin; Xu, Guoliang
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| 刊名 | PLOS ONE
 |
| 出版日期 | 2012 |
| 卷号 | 7期号:10页码:e47358 |
| 通讯作者 | Xu, GL (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China. |
| 英文摘要 | Methyl-CpG binding domain protein 5 (MBD5) belongs to the MBD family proteins, which play central roles in transcriptional regulation and development. The significance of MBD5 function is highlighted by recent studies implicating it as a candidate gene involved in human 2q23.1 microdeletion syndrome. To investigate the physiological role of Mbd5, we generated knockout mice. The Mbd5-deficient mice showed growth retardation, wasting and pre-weaning lethality. The observed growth retardation was associated with the impairment of GH/IGF-1 axis in Mbd5-null pups. Conditional knockout of Mbd5 in the brain resulted in the similar phenotypes as whole body deletion, indicating that Mbd5 functions in the nervous system to regulate postnatal growth. Moreover, the mutant mice also displayed enhanced glucose tolerance and elevated insulin sensitivity as a result of increased insulin signaling, ultimately resulting in disturbed glucose homeostasis and hypoglycemia. These results indicate Mbd5 as an essential factor for mouse postnatal growth and maintenance of glucose homeostasis. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | CPG-BINDING DOMAIN ; DNA METHYLATION ; MENTAL-RETARDATION ; POSTNATAL-GROWTH ; NERVOUS-SYSTEM ; FACTOR I ; HORMONE ; GENE ; INSULIN ; TRANSCRIPTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000309995100099 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/281]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Du, Yarui,Liu, Bo,Guo, Fan,et al. The Essential Role of Mbd5 in the Regulation of Somatic Growth and Glucose Homeostasis in Mice[J]. PLOS ONE,2012,7(10):e47358. |
| APA | Du, Yarui.,Liu, Bo.,Guo, Fan.,Xu, Guifang.,Ding, Yuqiang.,...&Xu, Guoliang.(2012).The Essential Role of Mbd5 in the Regulation of Somatic Growth and Glucose Homeostasis in Mice.PLOS ONE,7(10),e47358. |
| MLA | Du, Yarui,et al."The Essential Role of Mbd5 in the Regulation of Somatic Growth and Glucose Homeostasis in Mice".PLOS ONE 7.10(2012):e47358. |
入库方式： OAI收割
来源：上海营养与健康研究所
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