Midlife gene expressions identify modulators of aging through dietary interventions
文献类型：期刊论文
| 作者 | Zhou, Bing; Yang, Liu（杨柳）; Li, Shoufeng; Huang, Jialiang; Chen, Haiyang; Hou, Lei; Wang, Jinbo; Green, Christopher D.; Yan, Zhen; Huang, Xun |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2012 |
| 卷号 | 109期号:19页码:E1201-E1209 |
| 关键词 | systems biology diet-induced obesity |
| 通讯作者 | Liu, Y (reprint author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China. |
| 英文摘要 | Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under different dietary conditions, which resulted in different lifespans and aging-related phenotypes, we were able to identify genes and pathways that modulate the aging process. We found that pathways transcriptionally correlated with diet-modulated lifespan and physiological changes were enriched for lifespan-modifying genes. Intriguingly, mitochondrial gene expression correlated with lifespan and anticorrelated with aging-related pathological changes, whereas peroxisomal gene expression showed an opposite trend. Both organelles produce reactive oxygen species, a proposed causative factor of aging. This finding implicates a contribution of peroxisome to aging. Consistent with this hypothesis, lowering the expression levels of peroxisome proliferation genes decreased the cellular peroxide levels and extended the lifespan of Drosophila melanogaster and Caenorhabditis elegans. These findings show that transcriptional changes resulting from dietary interventions can effectively reflect causal factors in aging and identify previously unknown or under-appreciated longevity pathways, such as the peroxisome pathway. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | ELEGANS LIFE-SPAN ; MITOCHONDRIAL BIOGENESIS ; TRANSCRIPTIONAL PROFILE ; CAENORHABDITIS-ELEGANS ; HUMAN BRAIN ; C-ELEGANS ; AGED MICE ; RESTRICTION ; PEROXISOMES ; PATTERNS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304090600010 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/283]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Zhou, Bing,Yang, Liu,Li, Shoufeng,et al. Midlife gene expressions identify modulators of aging through dietary interventions[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2012,109(19):E1201-E1209. |
| APA | Zhou, Bing.,Yang, Liu.,Li, Shoufeng.,Huang, Jialiang.,Chen, Haiyang.,...&Han, Jing-Dong J..(2012).Midlife gene expressions identify modulators of aging through dietary interventions.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,109(19),E1201-E1209. |
| MLA | Zhou, Bing,et al."Midlife gene expressions identify modulators of aging through dietary interventions".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109.19(2012):E1201-E1209. |
入库方式： OAI收割
来源：上海营养与健康研究所
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