Herbal constituent sequoyitol improves hyperglycemia and glucose intolerance by targeting hepatocytes, adipocytes, and beta-cells
文献类型：期刊论文
| 作者 | Shen, Hong; Shao, Mengle; Cho, Kae Won; Wang, Suqing; Chen, Zheng; Sheng, Liang; Wang, Ting; Liu, Yong（刘勇） ; Rui, Liangyou
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| 刊名 | AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
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| 出版日期 | 2012 |
| 卷号 | 302期号:8页码:E932-E940 |
| 关键词 | insulin resistance diabetes hyperglycemia |
| 通讯作者 | Rui, LY (reprint author), Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA. |
| 英文摘要 | Herbal constituent sequoyitol improves hyperglycemia and glucose intolerance by targeting hepatocytes, adipocytes, and beta-cells. Am J Physiol Endocrinol Metab 302: E932-E940, 2012. First published January 31, 2012; doi:10.1152/ajpendo.00479.2011.-The prevalence of insulin resistance and type 2 diabetes increases rapidly; however, treatments are limited. Various herbal extracts have been reported to reduce blood glucose in animals with either genetic or dietary type 2 diabetes; however, plant extracts are extremely complex, and leading compounds remain largely unknown. Here we show that 5-O-methyl-myo-inositol (also called sequoyitol), a herbal constituent, exerts antidiabetic effects in mice. Sequoyitol was chronically administrated into ob/ob mice either orally or subcutaneously. Both oral and subcutaneous administrations of sequoyitol decreased blood glucose, improved glucose intolerance, and enhanced insulin signaling in ob/ob mice. Sequoyitol directly enhanced insulin signaling, including phosphorylation of insulin receptor substrate-1 and Akt, in both HepG2 cells (derived from human hepatocytes) and 3T3-L1 adipocytes. In agreement, sequoyitol increased the ability of insulin to suppress glucose production in primary hepatocytes and to stimulate glucose uptake into primary adipocytes. Furthermore, sequoyitol improved insulin signaling in INS-1 cells (a rat beta-cell line) and protected INS-1 cells from streptozotocin-or H2O2-induced injury. In mice with streptozotocin-induced beta-cell deficiency, sequoyitol treatments increased plasma insulin levels and decreased hyperglycemia and glucose intolerance. These results indicate that sequoyitol, a natural, water-soluble small molecule, ameliorates hyperglycemia and glucose intolerance by increasing both insulin sensitivity and insulin secretion. Sequoyitol appears to directly target hepatocytes, adipocytes, and beta-cells. Therefore, sequoyitol may serve as a new oral diabetes medication. |
| 类目[WOS] | Endocrinology & Metabolism ; Physiology |
| 研究领域[WOS] | Endocrinology & Metabolism ; Physiology |
| 关键词[WOS] | INSULIN-RECEPTOR SUBSTRATE-1 ; POLYCYSTIC-OVARY-SYNDROME ; CHIRO-INOSITOL ; RAT-LIVER ; RESISTANCE ; PHOSPHORYLATION ; PHOSPHATASE ; METABOLISM ; SER(307) ; PINITOL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000302730600004 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/284]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Shen, Hong,Shao, Mengle,Cho, Kae Won,et al. Herbal constituent sequoyitol improves hyperglycemia and glucose intolerance by targeting hepatocytes, adipocytes, and beta-cells[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,2012,302(8):E932-E940. |
| APA | Shen, Hong.,Shao, Mengle.,Cho, Kae Won.,Wang, Suqing.,Chen, Zheng.,...&Rui, Liangyou.(2012).Herbal constituent sequoyitol improves hyperglycemia and glucose intolerance by targeting hepatocytes, adipocytes, and beta-cells.AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,302(8),E932-E940. |
| MLA | Shen, Hong,et al."Herbal constituent sequoyitol improves hyperglycemia and glucose intolerance by targeting hepatocytes, adipocytes, and beta-cells".AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 302.8(2012):E932-E940. |
入库方式： OAI收割
来源：上海营养与健康研究所
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