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Adenosine Deaminases Acting on RNA, RNA Editing, and Interferon Action
文献类型：期刊论文
| 作者 | George, Cyril X.; Gan, Zhenji; Liu, Yong（刘勇） ; Samuel, Charles E.
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| 刊名 | JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
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| 出版日期 | 2011 |
| 卷号 | 31期号:1页码:99-117 |
| 通讯作者 | Samuel, CE (reprint author), Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA. |
| 英文摘要 | Adenosine deaminases acting on RNA (ADARs) catalyze adenosine (A) to inosine (I) editing of RNA that possesses double-stranded (ds) structure. A-to-I RNA editing results in nucleotide substitution, because I is recognized as G instead of A both by ribosomes and by RNA polymerases. A-to-I substitution can also cause dsRNA destabilization, as I: U mismatch base pairs are less stable than A: U base pairs. Three mammalian ADAR genes are known, of which two encode active deaminases (ADAR1 and ADAR2). Alternative promoters together with alternative splicing give rise to two protein size forms of ADAR1: an interferon-inducible ADAR1-p150 deaminase that binds dsRNA and Z-DNA, and a constitutively expressed ADAR1-p110 deaminase. ADAR2, like ADAR1-p110, is constitutively expressed and binds dsRNA. A-to-I editing occurs with both viral and cellular RNAs, and affects a broad range of biological processes. These include virus growth and persistence, apoptosis and embryogenesis, neurotransmitter receptor and ion channel function, pancreatic cell function, and post-transcriptional gene regulation by microRNAs. Biochemical processes that provide a framework for understanding the physiologic changes following ADAR-catalyzed A-to-I (-G) editing events include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA-structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology ; Immunology |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Cell Biology ; Immunology |
| 关键词[WOS] | DOUBLE-STRANDED-RNA ; HEPATITIS-DELTA VIRUS ; PROTEIN-KINASE PKR ; DYSCHROMATOSIS SYMMETRICA HEREDITARIA ; PRE-MESSENGER-RNA ; SPLICE-SITE VARIANTS ; Z-DNA BINDING ; AMPA RECEPTOR CHANNELS ; KCS-LIKE ELEMENT ; Z-ALPHA DOMAIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000286380000012 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/289]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | George, Cyril X.,Gan, Zhenji,Liu, Yong,et al. Adenosine Deaminases Acting on RNA, RNA Editing, and Interferon Action[J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH,2011,31(1):99-117. |
| APA | George, Cyril X.,Gan, Zhenji,Liu, Yong,&Samuel, Charles E..(2011).Adenosine Deaminases Acting on RNA, RNA Editing, and Interferon Action.JOURNAL OF INTERFERON AND CYTOKINE RESEARCH,31(1),99-117. |
| MLA | George, Cyril X.,et al."Adenosine Deaminases Acting on RNA, RNA Editing, and Interferon Action".JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 31.1(2011):99-117. |
入库方式： OAI收割
来源：上海营养与健康研究所
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