Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice
文献类型：期刊论文
| 作者 | Huang, Ping; Li, Shoufeng; Shao, Mengle; Qi, Qibin; Zhao, Feng; You, Jia; Mao, Ting; Li, Wenjun; Yan, Zhen; Liu, Yong（刘勇）
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| 刊名 | NUTRITION & METABOLISM
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| 出版日期 | 2010 |
| 卷号 | 7期号:1页码:59 |
| 通讯作者 | Yan, Z (reprint author), Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA. |
| 英文摘要 | Background: Calorie restriction (CR) and endurance exercise are known to attenuate obesity and improve the metabolic syndrome. The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance. Methods: Adult male C57BL/6N mice were randomly assigned and subjected to one of the six interventions for 8 weeks: low-fat diet (LC, 10% fat), low-fat diet with 30% calorie restriction (LR), high-fat diet (HC, 60% fat), high-fat diet with 30% calorie restriction (HR), high-fat diet with voluntary running exercise (HE), and high-fat diet with a combination of 30% calorie restriction and exercise (HRE). The impacts of the interventions were assessed by comprehensive metabolic analyses and pro-inflammatory cytokine gene expression. Results: Endurance exercise significantly attenuated high-fat diet-induced obesity. CR dramatically prevented high-fat diet-induced metabolic abnormalities. A combination of CR and endurance exercise further reduced obesity and insulin resistance under the condition of high-fat diet. CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal. Conclusions: CR and endurance exercise share a potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance. |
| 类目[WOS] | Nutrition & Dietetics |
| 研究领域[WOS] | Nutrition & Dietetics |
| 关键词[WOS] | WEIGHT-LOSS PROGRAM ; POLYUNSATURATED FATTY-ACIDS ; TYPE-2 DIABETES-MELLITUS ; C-REACTIVE PROTEIN ; POSTMENOPAUSAL WOMEN ; METABOLIC SYNDROME ; MACROPHAGE INFILTRATION ; CYTOKINE PRODUCTION ; SKELETAL-MUSCLE ; BODY-WEIGHT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000282490700001 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/293]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Huang, Ping,Li, Shoufeng,Shao, Mengle,et al. Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice[J]. NUTRITION & METABOLISM,2010,7(1):59. |
| APA | Huang, Ping.,Li, Shoufeng.,Shao, Mengle.,Qi, Qibin.,Zhao, Feng.,...&Liu, Yong.(2010).Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice.NUTRITION & METABOLISM,7(1),59. |
| MLA | Huang, Ping,et al."Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice".NUTRITION & METABOLISM 7.1(2010):59. |
入库方式： OAI收割
来源：上海营养与健康研究所
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