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SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals
文献类型：期刊论文
| 作者 | Song, Wei; Ren, Decheng; Li, Wenjun; Jiang, Lin; Cho, Kae Won; Huang, Ping; Fan, Chen; Song, Yiyun; Liu, Yong（刘勇） ; Rui, Liangyou
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| 刊名 | CELL METABOLISM
 |
| 出版日期 | 2010 |
| 卷号 | 11期号:5页码:427-437 |
| 通讯作者 | Liu, Y (reprint author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China. |
| 英文摘要 | SH2B1 is a key regulator of body weight in mammals. Here, we identified dSH2B as the Drosophila homolog of SH2B1. dSH2B bound to Chico and directly promoted insulin-like signaling. Disruption of dSH2B decreased insulin-like signaling and somatic growth in flies. dSH2B deficiency also increased hemolymph carbohydrate levels, whole-body lipid levels, life span, and resistance to starvation and oxidative stress. Systemic overexpression of dSH2B resulted in opposite phenotypes. dSH2B overexpression in fat body decreased lipid and glucose levels, whereas neuron-specific overexpression of dSH2B decreased oxidative resistance and life span. Genetic deletion of SH2B1 also resulted in growth retardation, obesity, and type 2 diabetes in mice; surprisingly, life span and oxidative resistance were reduced in SH2B1 null mice. These data suggest that dSH2B regulation of insulin-like signaling, growth, and metabolism is conserved in SH2B1, whereas dSH2B regulation of oxidative stress and longevity may be conserved in other SH2B family members. |
| 类目[WOS] | Cell Biology ; Endocrinology & Metabolism |
| 研究领域[WOS] | Cell Biology ; Endocrinology & Metabolism |
| 关键词[WOS] | INSULIN-RECEPTOR ; LIFE-SPAN ; FAT-BODY ; DROSOPHILA-MELANOGASTER ; NUTRIENT HOMEOSTASIS ; GLUCOSE-HOMEOSTASIS ; MICE ; ENERGY ; LEPTIN ; SENSITIVITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000277341000012 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/294]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Song, Wei,Ren, Decheng,Li, Wenjun,et al. SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals[J]. CELL METABOLISM,2010,11(5):427-437. |
| APA | Song, Wei.,Ren, Decheng.,Li, Wenjun.,Jiang, Lin.,Cho, Kae Won.,...&Rui, Liangyou.(2010).SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals.CELL METABOLISM,11(5),427-437. |
| MLA | Song, Wei,et al."SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals".CELL METABOLISM 11.5(2010):427-437. |
入库方式： OAI收割
来源：上海营养与健康研究所
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