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Signaling through Tyr(985) of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance

文献类型:期刊论文

作者You, Jia; Yu, Yue; Jiang, Lei; Li, Wenxia; Yu, Xinxin; Gonzalez, Lety; Yang, Guoqing; Ke, Zunji; Li, Wenjun; Li, Cai
刊名MOLECULAR AND CELLULAR BIOLOGY
出版日期2010
卷号30期号:7页码:1650-1659
通讯作者Liu, Y (reprint author), Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab, 294 Taiyuan Rd, Shanghai 200031, Peoples R China.
英文摘要Leptin regulates energy homeostasis through central activation of multiple signaling pathways mediated by Ob-Rb, the long form of leptin receptor. Leptin resistance underlies the pathogenic development of obesity, which is closely associated with environmental factors. To further understand the physiological function of leptin signaling mechanisms, we generated a knock- in line of mice (Y985F) expressing a mutant Ob-Rb with a phenylalanine substitution for Tyr(985), one of the three intracellular tyrosines that mediate leptin's signaling actions. Surprisingly, whereas young homozygous Y985F animals were slightly leaner, they exhibit adult-onset or diet-induced obesity. Importantly, both age-dependent and diet-induced deterioration of energy balance was paralleled with pronounced leptin resistance, which was largely attributable to attenuation of leptin-responsive hypothalamic STAT3 activation as well as prominently elevated expression of hypothalamic SOCS3, a key negative regulator of leptin signaling. Thus, these results unmask distinct binary roles for Try(985)-mediated signaling in energy metabolism, acting as an age/diet-dependent regulatory switch to counteract age-associated or diet-induced obesity.
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]DIET-INDUCED OBESITY ; BODY-WEIGHT ; FEEDBACK INHIBITION ; MITOCHONDRIAL STAT3 ; METABOLIC SYNDROME ; FOOD-INTAKE ; LONG FORM ; RESISTANCE ; MICE ; ACTIVATION
收录类别SCI
语种英语
WOS记录号WOS:000275302000007
公开日期2015-12-24
版本出版稿
源URL[http://202.127.25.144/handle/331004/295]  
专题中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组
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You, Jia,Yu, Yue,Jiang, Lei,et al. Signaling through Tyr(985) of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance[J]. MOLECULAR AND CELLULAR BIOLOGY,2010,30(7):1650-1659.
APA You, Jia.,Yu, Yue.,Jiang, Lei.,Li, Wenxia.,Yu, Xinxin.,...&Liu, Yong.(2010).Signaling through Tyr(985) of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance.MOLECULAR AND CELLULAR BIOLOGY,30(7),1650-1659.
MLA You, Jia,et al."Signaling through Tyr(985) of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance".MOLECULAR AND CELLULAR BIOLOGY 30.7(2010):1650-1659.

入库方式: OAI收割

来源:上海营养与健康研究所

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