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Signaling through Tyr(985) of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance
文献类型:期刊论文
作者 | You, Jia; Yu, Yue; Jiang, Lei; Li, Wenxia; Yu, Xinxin; Gonzalez, Lety; Yang, Guoqing; Ke, Zunji; Li, Wenjun; Li, Cai |
刊名 | MOLECULAR AND CELLULAR BIOLOGY |
出版日期 | 2010 |
卷号 | 30期号:7页码:1650-1659 |
通讯作者 | Liu, Y (reprint author), Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab, 294 Taiyuan Rd, Shanghai 200031, Peoples R China. |
英文摘要 | Leptin regulates energy homeostasis through central activation of multiple signaling pathways mediated by Ob-Rb, the long form of leptin receptor. Leptin resistance underlies the pathogenic development of obesity, which is closely associated with environmental factors. To further understand the physiological function of leptin signaling mechanisms, we generated a knock- in line of mice (Y985F) expressing a mutant Ob-Rb with a phenylalanine substitution for Tyr(985), one of the three intracellular tyrosines that mediate leptin's signaling actions. Surprisingly, whereas young homozygous Y985F animals were slightly leaner, they exhibit adult-onset or diet-induced obesity. Importantly, both age-dependent and diet-induced deterioration of energy balance was paralleled with pronounced leptin resistance, which was largely attributable to attenuation of leptin-responsive hypothalamic STAT3 activation as well as prominently elevated expression of hypothalamic SOCS3, a key negative regulator of leptin signaling. Thus, these results unmask distinct binary roles for Try(985)-mediated signaling in energy metabolism, acting as an age/diet-dependent regulatory switch to counteract age-associated or diet-induced obesity. |
类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
研究领域[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
关键词[WOS] | DIET-INDUCED OBESITY ; BODY-WEIGHT ; FEEDBACK INHIBITION ; MITOCHONDRIAL STAT3 ; METABOLIC SYNDROME ; FOOD-INTAKE ; LONG FORM ; RESISTANCE ; MICE ; ACTIVATION |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000275302000007 |
公开日期 | 2015-12-24 |
版本 | 出版稿 |
源URL | [http://202.127.25.144/handle/331004/295] |
专题 | 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
推荐引用方式 GB/T 7714 | You, Jia,Yu, Yue,Jiang, Lei,et al. Signaling through Tyr(985) of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance[J]. MOLECULAR AND CELLULAR BIOLOGY,2010,30(7):1650-1659. |
APA | You, Jia.,Yu, Yue.,Jiang, Lei.,Li, Wenxia.,Yu, Xinxin.,...&Liu, Yong.(2010).Signaling through Tyr(985) of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance.MOLECULAR AND CELLULAR BIOLOGY,30(7),1650-1659. |
MLA | You, Jia,et al."Signaling through Tyr(985) of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance".MOLECULAR AND CELLULAR BIOLOGY 30.7(2010):1650-1659. |
入库方式: OAI收割
来源:上海营养与健康研究所
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