Fenofibrate reduces serum retinol-binding protein-4 by suppressing its expression in adipose tissue
文献类型：期刊论文
| 作者 | Wu, Haiya; Wei, Li; Bao, Yuqian; Lu, Junxi; Huang, Ping; Liu, Yong（刘勇） ; Jia, Weiping; Xiang, Kunsan
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| 刊名 | AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
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| 出版日期 | 2009 |
| 卷号 | 296期号:4页码:E628-E634 |
| 关键词 | insulin resistance liver |
| 通讯作者 | Jia, WP (reprint author), Shanghai Jiao Tong Univ, Dept Endocrinol & Metab, Affiliated Peoples Hosp 6, Shanghai Diabet Inst,Shanghai Clin Ctr Diabet, 600 Yishan Rd, Shanghai 200233, Peoples R China. |
| 英文摘要 | Wu H, Wei L, Bao Y, Lu J, Huang P, Liu Y, Jia W, Xiang K. Fenofibrate reduces serum retinol-binding protein-4 by suppressing its expression in adipose tissue. Am J Physiol Endocrinol Metab 296: E628-E634, 2009. First published December 16, 2008; doi: 10.1152/ajpendo.90526.2008.-Fenofibrate is a peroxisome proliferator-activated receptor-alpha (PPAR alpha) activator that has been clinically used to treat dyslipidemia and insulin resistance. To better understand the molecular mechanisms underlying fenofibrate action, we investigated whether fenofibrate affects serum levels of retinol-binding protein-4 (RBP4), an adipocytokine that has recently been shown to link obesity and insulin resistance. Fenofibrate treatment significantly decreased serum RBP4 levels of dyslipidemic patients, which correlated with reduced body weight and increased insulin sensitivity. To elucidate the biochemical mechanisms of fenofibrate action, we investigated the effect of fenofibrate on RBP4 expression in obese rats. Fenofibrate greatly decreased RBP4 mRNA levels in adipose tissue but not in the liver, which correlated with decreased serum RBP4 levels and increased insulin sensitivity in obese rats. Consistent with a direct effect on RBP4 expression, fenofibrate treatment significantly reduced the mRNA expression levels of RPB4 in 3T3-L1 adipocytes. Together, our results demonstrate for the first time that fenofibrate inhibits RPB4 expression in dyslipidemic human subjects and suggest that inhibition of RBP4 expression in adipocytes may provide a mechanism by which fenofibrate improves insulin sensitivity in dyslipidemic patients. |
| 类目[WOS] | Endocrinology & Metabolism ; Physiology |
| 研究领域[WOS] | Endocrinology & Metabolism ; Physiology |
| 关键词[WOS] | MESSENGER-RNA LEVELS ; FATTY LIVER-DISEASE ; INSULIN-RESISTANCE ; DIABETES-MELLITUS ; CIRCULATING RETINOL-BINDING-PROTEIN-4 ; VISCERAL ADIPOSITY ; WEIGHT-LOSS ; OBESE ; ASSOCIATION ; ADIPONECTIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000264514900008 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/297]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Wu, Haiya,Wei, Li,Bao, Yuqian,et al. Fenofibrate reduces serum retinol-binding protein-4 by suppressing its expression in adipose tissue[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,2009,296(4):E628-E634. |
| APA | Wu, Haiya.,Wei, Li.,Bao, Yuqian.,Lu, Junxi.,Huang, Ping.,...&Xiang, Kunsan.(2009).Fenofibrate reduces serum retinol-binding protein-4 by suppressing its expression in adipose tissue.AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,296(4),E628-E634. |
| MLA | Wu, Haiya,et al."Fenofibrate reduces serum retinol-binding protein-4 by suppressing its expression in adipose tissue".AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 296.4(2009):E628-E634. |
入库方式： OAI收割
来源：上海营养与健康研究所
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