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Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis
文献类型：期刊论文
| 作者 | Jiang, Lei; You, Jia; Yu, Xinxin; Gonzalez, Lety; Yu, Yue; Wang, Qiong; Yang, Guoqing; Li, Wenjun; Li, Cai; Liu, Yong（刘勇）
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| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2008 |
| 卷号 | 105期号:47页码:18619-18624 |
| 关键词 | obesity insulin resistance knockin leptin signaling |
| 通讯作者 | Li, C (reprint author), Merck Res Labs, POB 2000, Rahway, NJ 07065 USA. |
| 英文摘要 | Leptin regulates energy balance and glucose metabolism by activation of multiple signaling cascades mediated by the long-form leptin receptor Ob-Rb. However, the whole spectrum of signaling actions through the 3 cytoplasmic tyrosines of mouse Ob-Rb remains to be completely defined in vivo. Here, we generated 2 knockin lines of mice expressing mutant leptin receptors with phenylailanine substitution for all 3 tyrosines (Y123F) or for Tyr(1138) alone (Y3F). Y123F animals developed overt obesity similar to that of Y3F animals with abrogated hypothalamic activation of STAT3 by leptin, but they exhibited more severe impairment in glucose tolerance. In striking contrast to db/db mice, however, both Y123F and Y3F mice showed attenuated adiposity with reduced hyperphagia, marked improvement in physical activity and adaptive thermogenesis, and significantly ameliorated glycemic control. Further, Y123F mice had hypothalamic neuropeptide Y/agouti-related protein expression maintained at prominently lower levels compared with db/db mice. Thus, these results provide direct physiological evidence that Ob-Rb exerts crucial metabolic actions not only through tyrosine-dependent, but also tyrosine-independent mechanisms in control of energy balance and glucose homeostasis. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | BODY-WEIGHT ; ADAPTIVE THERMOGENESIS ; OB/OB MICE ; LONG FORM ; PROTEIN ; OBESITY ; ACTIVATION ; SIGNALS ; SENSITIVITY ; EXPENDITURE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000261489300103 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/299]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Jiang, Lei,You, Jia,Yu, Xinxin,et al. Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2008,105(47):18619-18624. |
| APA | Jiang, Lei.,You, Jia.,Yu, Xinxin.,Gonzalez, Lety.,Yu, Yue.,...&Liu, Yong.(2008).Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,105(47),18619-18624. |
| MLA | Jiang, Lei,et al."Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105.47(2008):18619-18624. |
入库方式： OAI收割
来源：上海营养与健康研究所
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