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The Endoplasmic Reticulum Stress Sensor IRE1 alpha in Intestinal Epithelial Cells Is Essential for Protecting against Colitis
文献类型：期刊论文
| 作者 | Zhang, Hai-Sheng; Chen, Ying; Fan, Li; Xi, Qiu-Lei; Wu, Guo-Hao; Li, Xiu-Xiu; Yuan, Tang-Long; He, Sheng-Qi; Yu, Yue; Shao, Meng-Le |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 290期号:24页码:15327-15336 |
| 通讯作者 | Liu, Y (reprint author), Chinese Acad Sci, Lab Food Safety Res, Lab Nutr & Metab, Inst Nutrit Sci, Shanghai 200031, Peoples R China. |
| 英文摘要 | Intestinal epithelial cells (IECs) have critical roles in maintaining homeostasis of intestinal epithelium. Endoplasmic reticulum (ER) stress is implicated in intestinal epithelium homeostasis and inflammatory bowel disease; however, it remains elusive whether IRE1 alpha, a major sensor of ER stress, is directly involved in these processes. We demonstrate here that genetic ablation of Ire1 alpha in IECs leads to spontaneous colitis in mice. Deletion of IRE1 alpha in IECs results in loss of goblet cells and failure of intestinal epithelial barrier function. IRE1 alpha deficiency induces cell apoptosis through induction of CHOP, the pro-apoptotic protein, and sensitizes cells to lipopolysaccharide, an endotoxin from bacteria. IRE1 alpha deficiency confers upon mice higher susceptibility to chemical-induced colitis. These results suggest that IRE1 alpha functions to maintain the intestinal epithelial homeostasis and plays an important role in defending against inflammation bowel diseases. |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | INFLAMMATORY-BOWEL-DISEASE ; UNFOLDED PROTEIN RESPONSE ; ER STRESS ; TRANSMEMBRANE PROTEIN ; GOBLET CELLS ; APOPTOSIS ; BARRIER ; LIPOPOLYSACCHARIDE ; MECHANISMS ; KINASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356177300043 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/302]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Hai-Sheng,Chen, Ying,Fan, Li,et al. The Endoplasmic Reticulum Stress Sensor IRE1 alpha in Intestinal Epithelial Cells Is Essential for Protecting against Colitis[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2015,290(24):15327-15336. |
| APA | Zhang, Hai-Sheng.,Chen, Ying.,Fan, Li.,Xi, Qiu-Lei.,Wu, Guo-Hao.,...&Fang, Jing.(2015).The Endoplasmic Reticulum Stress Sensor IRE1 alpha in Intestinal Epithelial Cells Is Essential for Protecting against Colitis.JOURNAL OF BIOLOGICAL CHEMISTRY,290(24),15327-15336. |
| MLA | Zhang, Hai-Sheng,et al."The Endoplasmic Reticulum Stress Sensor IRE1 alpha in Intestinal Epithelial Cells Is Essential for Protecting against Colitis".JOURNAL OF BIOLOGICAL CHEMISTRY 290.24(2015):15327-15336. |
入库方式： OAI收割
来源：上海营养与健康研究所
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