TRAF6 is upregulated in colon cancer and promotes proliferation of colon cancer cells
文献类型：期刊论文
| 作者 | Sun, Heng; Li, Xuebing; Fan, li（范莉）; Wu, Guohao; Li, Min; Fang, Jing（方靖） |
| 刊名 | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
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| 出版日期 | 2014 |
| 卷号 | 53期号:0页码:195-201 |
| 关键词 | TRAF6 Colon cancer Cell proliferation Tumorigenesis |
| 通讯作者 | Fang, J (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai, Peoples R China. |
| 英文摘要 | TNF receptor associated factor 6 (TRAF6) plays a critical role in the regulation of innate immune responses and adaptive immune responses. Though recent studies indicate that TRAF6 is involved in cancer, its precise role in cancer including colon cancer has not been extensively investigated and remains largely unknown. The purpose of this work is to determine the expression of TRAF6 in colon cancer as well as the possible role of it in proliferation and apoptosis of colon cancer cells. Fifty colon cancer tissues paired with their adjacent non-cancerous tissues were analyzed. TRAF6 expression is upregulated in cancers (P = 0.000), which is correlated with tumor grades (P = 0.012). The tumor tissue-array analysis also indicates that expression of TRAF6 is upregulated in colon cancer (P = 0.000), but the TRAF6 upregulation has no association with patients' survival rate (P = 0.055). We found that knockdown of TRAF6 blocks proliferation of colon cancer cells through cyclin D1. Different from other reports, in our experiments knockdown of TRAF6 alone has little effect on survival of colon cancer cells examined. Knockdown of TRAF6 sensitizes the cells to treatment of the conventional anti-cancer drugs 5-fluorouracil and etoposide. Thus, inhibition of TRAF6 may improve the therapeutic treatment of these drugs. Together, our data suggest that TRAF6 promotes proliferation of colon cancer cells and it may serve as a potential target for therapy of colon cancer. (C) 2014 Elsevier Ltd. All rights reserved. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | CYCLIN D1 EXPRESSION ; COLORECTAL-CANCER ; IMMUNE-SYSTEM ; ACTIVATION ; CARCINOMA ; PATHWAYS ; UBIQUITINATION ; ANGIOGENESIS ; PHENOTYPE ; BETA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340340400024 |
| 公开日期 | 2015-12-24 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/331]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Sun, Heng,Li, Xuebing,Fan, li,et al. TRAF6 is upregulated in colon cancer and promotes proliferation of colon cancer cells[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2014,53(0):195-201. |
| APA | Sun, Heng,Li, Xuebing,Fan, li,Wu, Guohao,Li, Min,&Fang, Jing.(2014).TRAF6 is upregulated in colon cancer and promotes proliferation of colon cancer cells.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,53(0),195-201. |
| MLA | Sun, Heng,et al."TRAF6 is upregulated in colon cancer and promotes proliferation of colon cancer cells".INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 53.0(2014):195-201. |
入库方式： OAI收割
来源：上海营养与健康研究所
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