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A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth
文献类型：期刊论文
| 作者 | Zhang, Yuqing; Yang, Jingxuan; Cui, Xiaobo; Chen, Yong; Zhu, Vivian F.; Hagan, John P.; Wang, Huamin; Yu, Xianjun; Hodges, Sally E.; Fang, Jing（方靖） |
| 刊名 | EMBO MOLECULAR MEDICINE
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:9页码:1322-1334 |
| 关键词 | microRNA-373 pancreatic cancer zinc ZIP4 |
| 通讯作者 | Li, M (reprint author), Baylor Coll Med, Michael E DeBakey Dept Surg, Houston, TX 77030 USA. |
| 英文摘要 | Changes in the intracellular levels of the essential micronutrient zinc have been implicated in multiple diseases including pancreatic cancer; however, the molecular mechanism is poorly understood. Here, we report a novel mechanism where increased zinc mediated by the zinc importer ZIP4 transcriptionally induces miR-373 in pancreatic cancer to promote tumour growth. Reporter, expression and chromatin immunoprecipitation assays demonstrate that ZIP4 activates the zinc-dependent transcription factor CREB and requires this transcription factor to increase miR-373 expression through the regulation of its promoter. miR-373 induction is necessary for efficient ZIP4-dependent enhancement of cell proliferation, invasion, and tumour growth. Further analysis of miR-373 in vivo oncogenic function reveals that it is mediated through its negative regulation of TP53INP1, LATS2 and CD44. These results define a novel ZIP4-CREB-miR-373 signalling axis promoting pancreatic cancer growth, providing mechanistic insights explaining in part how a zinc transporter functions in cancer cells and may have broader implications as inappropriate regulation of intracellular zinc levels plays an important role in many other diseases. |
| 类目[WOS] | Medicine, Research & Experimental |
| 研究领域[WOS] | Research & Experimental Medicine |
| 关键词[WOS] | ZINC TRANSPORTER ; PROSTATE-CANCER ; ACRODERMATITIS-ENTEROPATHICA ; KAPPA-B ; EXPRESSION ; CELLS ; OVEREXPRESSION ; METASTASIS ; MICRORNAS ; PHENOTYPE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000323783000005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/332]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Yuqing,Yang, Jingxuan,Cui, Xiaobo,et al. A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth[J]. EMBO MOLECULAR MEDICINE,2013,5(9):1322-1334. |
| APA | Zhang, Yuqing.,Yang, Jingxuan.,Cui, Xiaobo.,Chen, Yong.,Zhu, Vivian F..,...&Li, Min.(2013).A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth.EMBO MOLECULAR MEDICINE,5(9),1322-1334. |
| MLA | Zhang, Yuqing,et al."A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth".EMBO MOLECULAR MEDICINE 5.9(2013):1322-1334. |
入库方式： OAI收割
来源：上海营养与健康研究所
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