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TRAF6 Upregulates Expression of HIF-1 alpha and Promotes Tumor Angiogenesis
文献类型：期刊论文
| 作者 | Sun, Heng; Li, Xue-Bing; Meng, Ya; Fan, li（范莉）; Li, Min; Fang, Jing（方靖） |
| 刊名 | CANCER RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 73期号:15页码:4950-4959 |
| 通讯作者 | Fang, J (reprint author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, SIBS, Shanghai 200031, Peoples R China. |
| 英文摘要 | TNF receptor (TNFR)-associated factor TRAF6 is a key activator of NF-kappa B, playing a critical role in the regulation of innate immune responses and their connection to adaptive immune responses. TRAF6 interactions determine receptor-induced cell death versus survival. TRAF6 has been implicated in cancer but its contributions have not been investigated deeply. In this study, we show that TRAF6 upregulates expression of hypoxia-inducible factor (HIF)-1 alpha. TRAF6 affects HIF-1 alpha protein levels but has little effect on mRNA level. TRAF6 increases HIF-1 alpha protein independent of oxygen. We found that TRAF6 binds HIF-1 alpha and mediates its K63-linked polyubiquitination. The E3 ligase activity of TRAF6 was required to increase HIF-1 alpha protein levels. Finally, we showed that TRAF6 promoted tumor angiogenesis and growth. Our results reveal how TRAF6 functions to upregulate HIF-1 alpha expression and promote tumor angiogenesis. Cancer Res; 73(15); 4950-9. (C) 2013 AACR. |
| 类目[WOS] | Oncology |
| 研究领域[WOS] | Oncology |
| 关键词[WOS] | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA ; CANCER-THERAPY ; UBIQUITINATION ; ACTIVATION ; CELLS ; INFLAMMATION ; CARCINOMA ; DEGRADATION ; PHENOTYPE ; PATHWAYS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000322620800034 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/333]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Sun, Heng,Li, Xue-Bing,Meng, Ya,et al. TRAF6 Upregulates Expression of HIF-1 alpha and Promotes Tumor Angiogenesis[J]. CANCER RESEARCH,2013,73(15):4950-4959. |
| APA | Sun, Heng,Li, Xue-Bing,Meng, Ya,Fan, li,Li, Min,&Fang, Jing.(2013).TRAF6 Upregulates Expression of HIF-1 alpha and Promotes Tumor Angiogenesis.CANCER RESEARCH,73(15),4950-4959. |
| MLA | Sun, Heng,et al."TRAF6 Upregulates Expression of HIF-1 alpha and Promotes Tumor Angiogenesis".CANCER RESEARCH 73.15(2013):4950-4959. |
入库方式： OAI收割
来源：上海营养与健康研究所
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