The von Hippel-Lindau Protein pVHL Inhibits Ribosome Biogenesis and Protein Synthesis
文献类型：期刊论文
| 作者 | Zhao, Wen-Ting; Zhou, Cheng-Fu; Li, Xue-Bing; Zhang, Yun-Fang; Fan, li（范莉）; Pelletier, Jerry; Fang, Jing（方靖） |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2013 |
| 卷号 | 288期号:23页码:16588-16597 |
| 通讯作者 | Fang, J (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China. |
| 英文摘要 | pVHL, the product of von Hippel-Lindau (VHL) tumor suppressor gene, functions as the substrate recognition component of an E3-ubiquitin ligase complex that targets hypoxia inducible factor alpha (HIF-alpha) for ubiquitination and degradation. Besides HIF-alpha, pVHL also interacts with other proteins and has multiple functions. Here, we report that pVHL inhibits ribosome biogenesis and protein synthesis. We find that pVHL associates with the 40S ribosomal protein S3 (RPS3) but does not target it for destruction. Rather, the pVHL-RPS3 association interferes with the interaction between RPS3 and RPS2. Expression of pVHL also leads to nuclear retention of pre-40S ribosomal subunits, diminishing polysomes and 18S rRNA levels. We also demonstrate that pVHL suppresses both cap-dependent and cap-independent protein synthesis. Our findings unravel a novel function of pVHL and provide insight into the regulation of ribosome biogenesis by the tumor suppressor pVHL. |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | TUMOR-SUPPRESSOR PROTEIN ; HUMAN BREAST-CANCER ; TRANSLATION INITIATION ; NUCLEAR EXPORT ; PRE-RIBOSOMES ; RNA SYNTHESIS ; SUBUNITS ; NETWORK ; GROWTH ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000320378900035 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/334]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Zhao, Wen-Ting,Zhou, Cheng-Fu,Li, Xue-Bing,et al. The von Hippel-Lindau Protein pVHL Inhibits Ribosome Biogenesis and Protein Synthesis[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2013,288(23):16588-16597. |
| APA | Zhao, Wen-Ting.,Zhou, Cheng-Fu.,Li, Xue-Bing.,Zhang, Yun-Fang.,Fan, li.,...&Fang, Jing.(2013).The von Hippel-Lindau Protein pVHL Inhibits Ribosome Biogenesis and Protein Synthesis.JOURNAL OF BIOLOGICAL CHEMISTRY,288(23),16588-16597. |
| MLA | Zhao, Wen-Ting,et al."The von Hippel-Lindau Protein pVHL Inhibits Ribosome Biogenesis and Protein Synthesis".JOURNAL OF BIOLOGICAL CHEMISTRY 288.23(2013):16588-16597. |
入库方式： OAI收割
来源：上海营养与健康研究所
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