A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression
文献类型：期刊论文
| 作者 | Li, Zongmeng; Mou, Haiwei; Wang, Ting; Xue, Jing; Deng, Bo; Qian, Lihua; Zhou, Ye; Gong, Wanghua; Wang, Ji Ming; Wu, Guohao |
| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2013 |
| 卷号 | 328期号:2页码:278-284 |
| 关键词 | FAM3B variant Colon cancer cell Slug Cell migration Metastasis |
| 通讯作者 | Fang, J (reprint author), Chinese Acad Sci, Grad Univ, Inst Nutrit Sci, Key Lab Nutr & Metab,SIBS, Shanghai, Peoples R China. |
| 英文摘要 | FAM3B mRNA has been predicted to have multiple splicing forms. Its secretory form PANDER is decreased in gastric cancers with high invasiveness and metastasis. Here we found that its non-secretory form FAM3B-258 was highly expressed in most colon cancer cell lines and colorectal adenocarcinoma tissues but not hepatocellular carcinoma, lung carcinoma and pancreatic adenocarcinoma cell lines. Elevation of FAM3B-258 was associated with poor cancer cell differentiation. Stable overexpression of FAM3B-258 in colon cancer cells downregulated adhesion proteins, upregulated Slug and Cdc42, promoted cell migration and invasion in vitro and metastasis in nude mice. Slug mediated FAM3B-258-induced downregulation of adhesion molecules, upregulation of Cdc42, and invasion of colon cancer cells. The expression of FAM3B-258 in human colorectal adenocarcinomas was positively correlated with Slug. These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug. (C) 2012 Elsevier Ireland Ltd. All rights reserved. |
| 类目[WOS] | Oncology |
| 研究领域[WOS] | Oncology |
| 关键词[WOS] | PANCREATIC-DERIVED FACTOR ; EPITHELIAL-MESENCHYMAL TRANSITIONS ; E-CADHERIN EXPRESSION ; RHO-FAMILY GTPASES ; COLORECTAL-CANCER ; BETA-CELLS ; CARCINOMA ; CYTOKINE ; PANDER ; SNAIL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000313138000012 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/336]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Li, Zongmeng,Mou, Haiwei,Wang, Ting,et al. A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression[J]. CANCER LETTERS,2013,328(2):278-284. |
| APA | Li, Zongmeng.,Mou, Haiwei.,Wang, Ting.,Xue, Jing.,Deng, Bo.,...&Le, Yingying.(2013).A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression.CANCER LETTERS,328(2),278-284. |
| MLA | Li, Zongmeng,et al."A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression".CANCER LETTERS 328.2(2013):278-284. |
入库方式： OAI收割
来源：上海营养与健康研究所
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