PAX2 Protein Induces Expression of Cyclin D1 through Activating AP-1 Protein and Promotes Proliferation of Colon Cancer Cells
文献类型：期刊论文
| 作者 | Zhang, Hai-Sheng; Yan, Bing; Li, Xue-Bing; Fan, li（范莉）; Zhang, Yun-Fang; Wu, Guo-Hao; Li, Min; Fang, Jing（方靖） |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2012 |
| 卷号 | 287期号:53页码:44164-44172 |
| 通讯作者 | Fang, J (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China. |
| 英文摘要 | Paired box (PAX) 2, a transcription factor, plays a critical role in embryogenesis. When aberrantly expressed in adult tissues, it generally exhibits oncogenic properties. However, the underlying mechanisms remain unclear. We reported previously that the expression of PAX2 was up-regulated in human colon cancers. However, the role of PAX2 in colon cancer cells has yet to be determined. The aim of this study is to determine the function of PAX2 in colon cancer cells and to investigate the possible mechanisms underlain. We find that knockdown of PAX2 inhibits proliferation and xenograft growth of colon cancer cells. Inhibition of PAX2 results in a decreased expression of cyclin D1. Expression of cyclin D1 is found increased in human primary colon malignant tumors, and its expression is associated with that of PAX2. These data indicate that PAX2 is a positive regulator of expression of cyclin D1. We find that knockdown of PAX2 inhibits the activity of AP-1, a transcription factor that induces cyclin D1 expression, implying that PAX2 induces cyclin D1 through AP-1. PAX2 has little effect on expression of AP-1 members including c-Jun, c-Fos, and JunB. Our data show that PAX2 prevents JunB from binding c-Jun and enhances phosphorylation of c-Jun, which may elevate the activity of AP-1. Taken together, these results suggest that PAX2 promotes proliferation of colon cancer cells through AP-1. |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | C-JUN ; COLORECTAL-CANCER ; CARCINOMA CELLS ; BETA-CATENIN ; KAPPA-B ; TUMORIGENESIS ; PHOSPHORYLATION ; APOPTOSIS ; TARGET ; GENES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000312938600015 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/337]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Hai-Sheng,Yan, Bing,Li, Xue-Bing,et al. PAX2 Protein Induces Expression of Cyclin D1 through Activating AP-1 Protein and Promotes Proliferation of Colon Cancer Cells[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2012,287(53):44164-44172. |
| APA | Zhang, Hai-Sheng.,Yan, Bing.,Li, Xue-Bing.,Fan, li.,Zhang, Yun-Fang.,...&Fang, Jing.(2012).PAX2 Protein Induces Expression of Cyclin D1 through Activating AP-1 Protein and Promotes Proliferation of Colon Cancer Cells.JOURNAL OF BIOLOGICAL CHEMISTRY,287(53),44164-44172. |
| MLA | Zhang, Hai-Sheng,et al."PAX2 Protein Induces Expression of Cyclin D1 through Activating AP-1 Protein and Promotes Proliferation of Colon Cancer Cells".JOURNAL OF BIOLOGICAL CHEMISTRY 287.53(2012):44164-44172. |
入库方式： OAI收割
来源：上海营养与健康研究所
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