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Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells
文献类型：期刊论文
| 作者 | Zhou, Cheng-Fu; Li, Xue-Bing; Sun, Heng; Zhang, Bo; Han, Yu-Song; Jiang, Yi; Zhuang, Qiu-Lin; Fang, Jing（方靖）; Wu, Guo-Hao |
| 刊名 | IUBMB LIFE
 |
| 出版日期 | 2012 |
| 卷号 | 64期号:9页码:775-782 |
| 关键词 | colorectal cancer cell proliferation cellular glucose metabolism migration protein function protein expression pyruvate kinase |
| 通讯作者 | Wu, GH (reprint author), Fudan Univ, Sch Med, Zhongshan Hosp, Dept Surg, Shanghai 200032, Peoples R China. |
| 英文摘要 | Pyruvate kinase type M2 (PKM2) has been reported to be involved in aerobic glycolysis and cell growth in various tumors. However, the expression pattern of PKM2 in colorectal cancer (CRC) and the correlation between PKM2 expression and CRC remains unclear. The aim of this study is to investigate PKM2 expression and its possible role in CRC. We found that expression of PKM2 was increased in CRC and the increased PKM2 expression was associated with later stage and lymph metastasis of the tumors. Knockdown of PKM2 suppressed the aerobic glycolysis and decreased lactate production of colon cancer RKO cells. Knockdown of PKM2 repressed proliferation and migration of the cells. Inhibition of PKM2 suppressed xenograft tumor growth of RKO cells in vivo. These results suggest that the expression of PKM2 plays a critical role in development of CRC, and it may provide a growth advantage for colon cancer cells. Thus, PKM2 might be a potential therapeutic target for CRC. (c) 2012 IUBMB Life, 64(9): 775782, 2012 |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | HUMAN-PAPILLOMAVIRUS TYPE-16 ; TUMOR-GROWTH ; E7 ONCOPROTEIN ; INVASION ; METABOLISM ; GLYCOLYSIS ; EXPRESSION ; PKM2 ; TRANSFORMATION ; TUMORIGENESIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000307886700008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/338]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Zhou, Cheng-Fu,Li, Xue-Bing,Sun, Heng,et al. Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells[J]. IUBMB LIFE,2012,64(9):775-782. |
| APA | Zhou, Cheng-Fu.,Li, Xue-Bing.,Sun, Heng.,Zhang, Bo.,Han, Yu-Song.,...&Wu, Guo-Hao.(2012).Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells.IUBMB LIFE,64(9),775-782. |
| MLA | Zhou, Cheng-Fu,et al."Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells".IUBMB LIFE 64.9(2012):775-782. |
入库方式： OAI收割
来源：上海营养与健康研究所
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