The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells
文献类型：期刊论文
| 作者 | Li, Xue-bing; Jiao, Shi; Sun, Heng; Xue, Jing; Zhao, Wen-ting; Fan, li（范莉）; Wu, Guo-hao; Fang, Jing（方靖） |
| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2011 |
| 卷号 | 309期号:2页码:137-144 |
| 关键词 | EAR2 Orphan nuclear receptor Colorectal cancer |
| 通讯作者 | Wu, GH (reprint author), Fudan Univ, Sch Med, Zhongshan Hosp, Dept Surg, Shanghai 200031, Peoples R China. |
| 英文摘要 | EAR2 is a member of the chick ovalbumin upstream promoter-transcription factors (COUP-TFs). COUP-TFs belong to orphan nuclear receptors and regulate many biological processes. Little is known regarding EAR2 in cancer, though much progress has been made in understanding the function of other COUP-TF members. The aim of this study is to investigate the expression and possible function of EAR2 in colorectal cancer. We determined expression of EAR2 in human primary colorectal malignant tumors and their paired adjacent normal colorectal tissues. We found that expression of EAR2 was upregulated in colorectal tumors. Knockdown of EAR2 induced apoptosis of colon cancer cells, suggesting that EAR2 may function to regulate survivability of colon cancer cells. In vivo tumor study demonstrated that knockdown of EAR2 inhibited the xenograft growth of colon cancer cells. We found that knockdown of EAR2 inhibited the expression of X-linked inhibitor of apoptosis protein (XIAP), suggesting that EAR2 regulates cell survivability, at least partly, through XIAP. In this manuscript, we demonstrated that expression of EAR2 was elevated in colorectal cancer and knockdown of EAR2 reduced survivability and tumor growth of colon cancer cells. Our results suggest that EAR2 plays an important role in development of colorectal cancer. The findings also suggest that EAR2 may serve as a potential therapeutic target of colorectal cancer. (C) 2011 Elsevier Ireland Ltd. All rights reserved. |
| 类目[WOS] | Oncology |
| 研究领域[WOS] | Oncology |
| 关键词[WOS] | PROMOTER-TRANSCRIPTION FACTORS ; COUP-TFII ; APOPTOSIS ; GENE ; IDENTIFICATION ; ANGIOGENESIS ; SUPERFAMILY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000294576400003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/342]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Li, Xue-bing,Jiao, Shi,Sun, Heng,et al. The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells[J]. CANCER LETTERS,2011,309(2):137-144. |
| APA | Li, Xue-bing.,Jiao, Shi.,Sun, Heng.,Xue, Jing.,Zhao, Wen-ting.,...&Fang, Jing.(2011).The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells.CANCER LETTERS,309(2),137-144. |
| MLA | Li, Xue-bing,et al."The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells".CANCER LETTERS 309.2(2011):137-144. |
入库方式： OAI收割
来源：上海营养与健康研究所
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