Prolyl hydroxylase domain protein 3 targets Pax2 for destruction
文献类型：期刊论文
| 作者 | Yan, Bing; Jiao, Shi; Zhang, Hai-sheng; Lv, Dan-dan; Xue, Jing; Fan, li（范莉）; Wu, Guo-hao; Fang, Jing（方靖） |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2011 |
| 卷号 | 409期号:2页码:315-320 |
| 关键词 | PHD3 Pax2 Cancer |
| 通讯作者 | Wu, GH (reprint author), Fudan Univ, Sch Med, Dept Surg, Zhong Shan Hosp, Shanghai 200031, Peoples R China. |
| 英文摘要 | Prolyl hydroxylase domain proteins (PHDs) hydroxylate HIF alpha in the presence of oxygen, leading to HIF alpha proteasomal destruction. The PHDs family comprises PHD1, 2, and 3. Recent studies indicate that, in addition to HIF alpha, PHDs have other substrates. Paired box (Pax) 2, a transcription factor, was found aberrantly expressed in a variety of cancers. However, the underlying mechanisms remain unknown. Here we demonstrate that PHD3 is a negative regulator of expression of Pax2. We found that PHD3 bound to Pax2 and mediated Pax2 destruction directly. Inhibition of PHD3 hydroxylase activity led to upregulation of Pax2 protein but not mRNA level. We found that Pax2 protein was increased and PHD3 protein was decreased in colorectal cancer, and the increased Pax2 was associated with decreased PHD3. Our results suggest that PHD3 targets Pax2 for destruction. The findings may disclose a mechanism for the regulation of Pax2 expression in cancer cells. (C) 2011 Elsevier Inc. All rights reserved. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | HIF-ALPHA ; CANCER ; GENES ; UBIQUITYLATION ; STABILITY ; FAMILY ; EGLN3 ; VHL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000291779100029 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/343]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Yan, Bing,Jiao, Shi,Zhang, Hai-sheng,et al. Prolyl hydroxylase domain protein 3 targets Pax2 for destruction[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,409(2):315-320. |
| APA | Yan, Bing.,Jiao, Shi.,Zhang, Hai-sheng.,Lv, Dan-dan.,Xue, Jing.,...&Fang, Jing.(2011).Prolyl hydroxylase domain protein 3 targets Pax2 for destruction.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,409(2),315-320. |
| MLA | Yan, Bing,et al."Prolyl hydroxylase domain protein 3 targets Pax2 for destruction".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 409.2(2011):315-320. |
入库方式： OAI收割
来源：上海营养与健康研究所
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