Activating Transcription Factor 3 Regulates Survivability and Migration of Vascular Smooth Muscle Cells
文献类型：期刊论文
| 作者 | Lv, Dandan; Meng, Dan; Zou, Fang-Fang; Fan, li（范莉）; Zhang, Ping; Yu, Ying（余鹰） ; Fang, Jing（方靖）
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| 刊名 | IUBMB LIFE
 |
| 出版日期 | 2011 |
| 卷号 | 63期号:1页码:62-69 |
| 关键词 | ATF3 VSMCs apoptosis migration |
| 通讯作者 | Fang, J (reprint author), Chinese Acad Sci, SIBS, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China. |
| 英文摘要 | Activating transcription factor 3 (ATF3) is a member of the ATF/CREB (CAMP responsive element binding protein) family of transcription factors. The expression and the function of ATF3 in vascular smooth muscle cells (VSMCs) remain unknown. The aim of this work is to determine the expression and possible function of ATF3 in VSMCs. We found that VSMCs expressed ATF3, and expression of ATF3 in VSMCs was induced by a variety of stimuli including serum, angiotensin II, and H(2)O(2). Knockdown of ATF3 induced apoptosis of VSMCs, caspase-3 cleavage, and cytochrome c release. The results suggest that ATF3 regulates survivability of VSMCs. Moreover, we found that overexpression of ATF3 promoted migration of VSMCs and induced expression of matrix metalloproteinase 1, 3, and 13. These results suggest that ATF3 plays a role in regulating migration of VSMCs. In addition, we found that the expression of ATF3 was upregulated in smooth muscle cells in the injured mouse femoral arteries compared with the uninjured control group. These results suggest that ATF3 is relevant to disease physiology. (C) 2011 IUBMB IUBMB Life, 63(1): 62-69, 2011 |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | GROWTH-FACTOR ; MATRIX METALLOPROTEINASES ; RECEPTOR TRANSACTIVATION ; REPRESSOR ATF3/LRF1 ; ENDOTHELIAL-CELLS ; INDUCED APOPTOSIS ; CANCER CELLS ; ATF3 ; EXPRESSION ; DEATH |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000287677100010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/345]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 中国科学院上海生命科学研究院营养科学研究所_磷脂代谢与心血管疾病研究组 |
| 推荐引用方式 GB/T 7714 | Lv, Dandan,Meng, Dan,Zou, Fang-Fang,et al. Activating Transcription Factor 3 Regulates Survivability and Migration of Vascular Smooth Muscle Cells[J]. IUBMB LIFE,2011,63(1):62-69. |
| APA | Lv, Dandan.,Meng, Dan.,Zou, Fang-Fang.,Fan, li.,Zhang, Ping.,...&Fang, Jing.(2011).Activating Transcription Factor 3 Regulates Survivability and Migration of Vascular Smooth Muscle Cells.IUBMB LIFE,63(1),62-69. |
| MLA | Lv, Dandan,et al."Activating Transcription Factor 3 Regulates Survivability and Migration of Vascular Smooth Muscle Cells".IUBMB LIFE 63.1(2011):62-69. |
入库方式： OAI收割
来源：上海营养与健康研究所
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