Discrepancy of biologic behavior influenced by bone marrow derived cells in lung cancer
文献类型：期刊论文
| 作者 | Zhang, Jie; Niu, Xiao-Min; Liao, Mei-Lin; Liu, Yun; Sha, Hui-Fang; Zhao, Yi; Yu, Yong-Feng; Tan, Qiang; Xiang, Jia-Qing; Fang, Jing（方靖） |
| 刊名 | ONCOLOGY REPORTS
 |
| 出版日期 | 2010 |
| 卷号 | 24期号:5页码:1185-1192 |
| 关键词 | bone stromal cells lung cancer biologic behavior |
| 通讯作者 | Lu, S (reprint author), Jiao Tong Univ, Shanghai Chest Hosp, Shanghai Lung Canc Ctr, Shanghai 200030, Peoples R China. |
| 英文摘要 | Disseminated cancer cells may initially require local nutrients and growth factors to thrive and survive in bone marrow. However, data on the influence of bone marrow derived cells (BMDC, also called bone stromal cells in some publications) on lung cancer cells is largely unexplored. This study explored the mechanism of how bone stromal factors contribute to the bone tropism in lung cancer. The difference among lung cancer cell lines in their abilities to metastasize to bone was found using the SCID animal model. Supernatant of bone marrow aspiration (BM) and condition medium from human bone stromal cells (BSC) were used to study the activity of bone stromal factors. We found bone stromal factors significantly increased the proliferation, invasion, adhesion and expression of angiogenosis-related factors, and inhibited the apoptosis for high bone metastasis H460 lung cancer cells. These biologic effects were not seen in SPC-A1 or A549 cells, which are low bone metastasis lung cancer cells. Adhesion of H460 cells to surface coated with bone stromal cells can activate some signal transduction pathways, and alter the expression of adhesion associated factors, including integrin beta 3 and ADAMTS-1, two potential targets related with bone metastasis. We concluded that bone marrow derived cells had a profound. effect on biological behavior of lung cancers, therefore favoring the growth of lung cancer cells in bone. |
| 类目[WOS] | Oncology |
| 研究领域[WOS] | Oncology |
| 关键词[WOS] | SIGNALING PROMOTES ; TUMOR-CELLS ; METASTASIS ; CARCINOMAS ; EXPRESSION ; PROTEIN ; GROWTH ; MICE ; FIBROBLASTS ; MECHANISMS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000283112200010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/346]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Jie,Niu, Xiao-Min,Liao, Mei-Lin,et al. Discrepancy of biologic behavior influenced by bone marrow derived cells in lung cancer[J]. ONCOLOGY REPORTS,2010,24(5):1185-1192. |
| APA | Zhang, Jie.,Niu, Xiao-Min.,Liao, Mei-Lin.,Liu, Yun.,Sha, Hui-Fang.,...&Chen, Hai-Quan.(2010).Discrepancy of biologic behavior influenced by bone marrow derived cells in lung cancer.ONCOLOGY REPORTS,24(5),1185-1192. |
| MLA | Zhang, Jie,et al."Discrepancy of biologic behavior influenced by bone marrow derived cells in lung cancer".ONCOLOGY REPORTS 24.5(2010):1185-1192. |
入库方式： OAI收割
来源：上海营养与健康研究所
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