Apigenin inhibits proliferation of ovarian cancer A2780 cells through Id1
文献类型：期刊论文
| 作者 | Li, Zhao-dong; Hu, Xiao-wen; Wang, Yu-tian; Fang, Jing（方靖） |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2009 |
| 卷号 | 583期号:12页码:1999-2003 |
| 关键词 | Apigenin Id1 Ovarian cancer |
| 通讯作者 | Fang, J (reprint author), Chinese Acad Sci, SIBS, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China. |
| 英文摘要 | Apigenin, a common dietary flavonoid, has been shown to possess anti-tumor properties. However, the mechanism by which apigenin inhibits cancer cells is not fully understood. Id1 (inhibitor of differentiation or DNA binding protein 1) contributes to tumorigenesis by stimulating cell proliferation, inhibiting cell differentiation and facilitating tumor neoangiogenesis. Elevated Id1 is found in ovarian cancers and its level correlates with the malignant potential of ovarian tumors. Therefore, Id1 is a potential target for ovarian cancer treatment. Here, we demonstrate that apigenin inhibits proliferation and tumorigenesis of human ovarian cancer A2780 cells through Id1. Apigenin suppressed the expression of Id1 through activating transcription factor 3 (ATF3). Our results may elucidate a new mechanism underlying the inhibitory effects of apigenin on cancer cells. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | FACTOR-BINDING PROTEIN-3 ; ATHYMIC NUDE-MICE ; BREAST-CANCER ; GROWTH-FACTOR ; TRANSCRIPTION FACTOR ; SIGNALING PATHWAY ; FLAVONOID INTAKE ; ID-1 EXPRESSION ; CARCINOMA-CELLS ; LUNG-CANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000267797800030 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/349]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Li, Zhao-dong,Hu, Xiao-wen,Wang, Yu-tian,et al. Apigenin inhibits proliferation of ovarian cancer A2780 cells through Id1[J]. FEBS LETTERS,2009,583(12):1999-2003. |
| APA | Li, Zhao-dong,Hu, Xiao-wen,Wang, Yu-tian,&Fang, Jing.(2009).Apigenin inhibits proliferation of ovarian cancer A2780 cells through Id1.FEBS LETTERS,583(12),1999-2003. |
| MLA | Li, Zhao-dong,et al."Apigenin inhibits proliferation of ovarian cancer A2780 cells through Id1".FEBS LETTERS 583.12(2009):1999-2003. |
入库方式： OAI收割
来源：上海营养与健康研究所
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