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Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin
文献类型：期刊论文
| 作者 | Zhou, Qiong; Yan, Bing; Hu, Xiaowen; Li, Xue-Bing; Zhang, Jie; Fang, Jing（方靖） |
| 刊名 | MOLECULAR CANCER THERAPEUTICS
 |
| 出版日期 | 2009 |
| 卷号 | 8期号:6页码:1684-1691 |
| 通讯作者 | Fang, J (reprint author), Chinese Acad Sci, SIBS, Inst Nutr Sci, Key Lab Nutr & Metab,Grad Sch, Shanghai 200031, Peoples R China. |
| 英文摘要 | Luteolin, a common dietary flavonoid, has been found to have antitumor properties and therefore poses special interest for the development of preventive and/or therapeutic agent for cancers. E-cadherin, a marker of epithelial cells, mediates cell-cell adhesion. Decreased expression of E-cadherin results in a loss of cell-cell adhesion an an increased cell invasion. Many studies have shown the antiproliferative activities of luteolin on cancer cells. However, the effects of luteolin on invasion of cancer cells remain unclear. In this article, we show that luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin. We found that Luteolin induced expression of E-cadherin through mdm2. Overexpression of mdm2 or knockdown of E-cadherin could restore invasion of PC3 cells after luteolin treatment. Luteolin inhibits mdm2 through AKT and overexpression of active AKT attenuated luteolin-induced expression of E-cadherin, suggesting that luteolin regulates E-cadherin through AKT/mdm2 pathway. The in vivo experiments showed that luteolin inhibited spontaneous lung metastasis of PC3 cells implanted onto the nude mice. These findings provide a new sight into the mechanisms that luteolin is against cancer cells, and suggest that molecular targeting of E-cadherin by luteolin may be a useful strategy for treatment of invasive prostate cancers. [Mol Cancer Ther 2009;8(6):1684-91] |
| 类目[WOS] | Oncology |
| 研究领域[WOS] | Oncology |
| 关键词[WOS] | GROWTH-FACTOR RECEPTOR ; LUNG-CANCER ; TUMOR-CELLS ; DIETARY FLAVONOIDS ; TYROSINE KINASE ; BREAST-CANCER ; EXPRESSION ; APOPTOSIS ; ADHESION ; RISK |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000267043100029 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/350]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Zhou, Qiong,Yan, Bing,Hu, Xiaowen,et al. Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin[J]. MOLECULAR CANCER THERAPEUTICS,2009,8(6):1684-1691. |
| APA | Zhou, Qiong,Yan, Bing,Hu, Xiaowen,Li, Xue-Bing,Zhang, Jie,&Fang, Jing.(2009).Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin.MOLECULAR CANCER THERAPEUTICS,8(6),1684-1691. |
| MLA | Zhou, Qiong,et al."Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin".MOLECULAR CANCER THERAPEUTICS 8.6(2009):1684-1691. |
入库方式： OAI收割
来源：上海营养与健康研究所
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