Benzo[a]pyrene induces expression of matrix metalloproteinases and cell migration and invasion of vascular smooth muscle cells
文献类型：期刊论文
| 作者 | Meng, Dan; Lv, Dan-Dan; Zhuang, Xuliang; Sun, Heng; Fan, Li; Shi, Xiang-Lin; Fang, Jing（方靖） |
| 刊名 | TOXICOLOGY LETTERS
 |
| 出版日期 | 2009 |
| 卷号 | 184期号:1页码:44-49 |
| 关键词 | Benzo[a]pyrene Vascular smooth muscle cells Migration Invasion Matrix metalloproteinases Aryl hydrocarbon receptor |
| 通讯作者 | Fang, J (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Benzo[a]pyrene (B[a]P) has been shown to accelerate atherosclerosis development in animal models. However, the mechanisms that B[a]P induces atherogenesis are unclear. Abnormal migration and invasion of vascular smooth muscle cells (VSMCs) is a major contributor to the development of atherosclerotic lesions. In this article, we demonstrated that B[a]P promoted the migration and invasion of rat VSMCs. B[a]P increased the mRNA levels of matrix metalloproteinase (MMP) 1, 2, 3, and 9. The MMPs inhibitor GM6001 inhibited B[a]P-induced invasion of VSMCs. Among the MMPs mentioned above, MMP-3 had the maximal induction. Mechanistic studies indicate that B[a]P-induced transcriptional activation of MMP-3 is not mediated by AP-1, NF-kappa B. B[a]P-induced expression of MMPs was attenuated by alpha-naphthoflavone, the aryl hydrocarbon receptor antagonist. In addition, alpha-naphthoflavone inhibited B[a]P-induced migration and invasion of VSMCs. These results suggest that the aryl hydrocarbon receptor plays an important role in B[a]P-induced expression of MMPs and migration and invasion of VSMC. Our findings may reveal a novel role of B[a]P in inducing atherogenesis. (C) 2008 Elsevier Ireland Ltd. All rights reserved. |
| 类目[WOS] | Toxicology |
| 研究领域[WOS] | Toxicology |
| 关键词[WOS] | POLYCYCLIC AROMATIC-HYDROCARBONS ; NF-KAPPA-B ; GENE-EXPRESSION ; GROWTH-FACTOR ; ATHEROSCLEROSIS ; BIOACTIVATION ; ATHEROGENESIS ; CARCINOGENS ; INDUCTION ; DISEASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000262544400008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/351]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Meng, Dan,Lv, Dan-Dan,Zhuang, Xuliang,et al. Benzo[a]pyrene induces expression of matrix metalloproteinases and cell migration and invasion of vascular smooth muscle cells[J]. TOXICOLOGY LETTERS,2009,184(1):44-49. |
| APA | Meng, Dan.,Lv, Dan-Dan.,Zhuang, Xuliang.,Sun, Heng.,Fan, Li.,...&Fang, Jing.(2009).Benzo[a]pyrene induces expression of matrix metalloproteinases and cell migration and invasion of vascular smooth muscle cells.TOXICOLOGY LETTERS,184(1),44-49. |
| MLA | Meng, Dan,et al."Benzo[a]pyrene induces expression of matrix metalloproteinases and cell migration and invasion of vascular smooth muscle cells".TOXICOLOGY LETTERS 184.1(2009):44-49. |
入库方式： OAI收割
来源：上海营养与健康研究所
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