Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers
文献类型：期刊论文
| 作者 | Ren, Wenzhi ; Zeng, Leyong ; Shen, Zheyu ; Xiang, Lingchao ; Gong, An ; Zhang, Jichao（张继超） ; Mao, Chengwen ; Li, Aiguo（李爱国） ; Paunesku, Tatjana ; Woloschak, Gayle E. ; Hosmane, Narayan S. ; Wu, Aiguo |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2013 |
| 卷号 | 3期号:43页码:CONCATENATE(Sheet1!I116,-Sheet1!J116) |
| ISSN号 | 2046-2069 |
| 英文摘要 | In order to overcome the multidrug resistance of breast cancer cells, doxorubicin was loaded onto TiO2 nanoparticles in which the electrostatic interactions hold the drug and the nanoparticles together. The anticancer activity of this nanocomposite was evaluated in multidrug resistant breast cancer cells. In nanocomposite treated MCF-7/ADM cells, drug accumulation increased with enhanced anticancer activity about 2.4 times compared to that of doxorubicin alone. The potential mechanism of enhanced drug accumulation is ascribed to the fact that the nanocomposite directly transports the drugs into cells via internalization, bypassing the P-glycoprotein mediated doxorubicin pumping system. Our results reinforce that the nanocomposite, as a pH controlled drug release system, could be used to overcome multidrug resistance of human breast cancer cells. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000325950600167 |
| 公开日期 | 2014-06-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13613]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Ren, Wenzhi,Zeng, Leyong,Shen, Zheyu,et al. Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers[J]. RSC ADVANCES,2013,3(43):CONCATENATE(Sheet1!I116,-Sheet1!J116). |
| APA | Ren, Wenzhi.,Zeng, Leyong.,Shen, Zheyu.,Xiang, Lingchao.,Gong, An.,...&Wu, Aiguo.(2013).Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers.RSC ADVANCES,3(43),CONCATENATE(Sheet1!I116,-Sheet1!J116). |
| MLA | Ren, Wenzhi,et al."Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers".RSC ADVANCES 3.43(2013):CONCATENATE(Sheet1!I116,-Sheet1!J116). |
入库方式： OAI收割
来源：上海应用物理研究所
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