The effect of hemiketals on the relaxivity of endohedral gadofullerenols
文献类型：期刊论文
| 作者 | Zou, Toujun1,2; Zhen, Mingming1; Li, Jie1,2; Chen, Daiqin1,2; Feng, Yongqiang1,2; Li, Ruimin1,2; Guan, Mirong1,2; Zhang, Ying1,2; Shu, Chunying1; Wang, Chunru1 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:117页码:96253-96257 |
| 英文摘要 | Gadofullerenols have received much attention due to their high relaxivities and low-toxicity as magnetic resonance imaging (MRI) contrast agents. However, the relaxivities of gadofullerenols vary in different reports. In this study, Gd@C-82(OH)(x)O-y with different hemiketal content were synthesized and the influence of this factor on water proton relaxation was investigated. The results show that Gd@C-82(OH)(x)O-y with more hemiketals exhibit much higher relaxivities than those with fewer hemiketals. The hemiketal structure is supposed to promote the formation of intermolecular hydrogen bonds, and finally lead to large aggregates. This is consistent with a previous report that the relaxivities of endohedral gadofullerene derivatives are strongly associated with the aggregate size. Hence, this work provides an important strategy for the manipulation of the relaxivities of gadofullerene based MRI contrast agents by controlling the quantity of hemiketals on the carbon cage. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-12-29 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29302]  |
| 专题 | 化学研究所_分子纳米结构与纳米技术实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zou, Toujun,Zhen, Mingming,Li, Jie,et al. The effect of hemiketals on the relaxivity of endohedral gadofullerenols[J]. RSC ADVANCES,2015,5(117):96253-96257. |
| APA | Zou, Toujun.,Zhen, Mingming.,Li, Jie.,Chen, Daiqin.,Feng, Yongqiang.,...&Wang, Chunru.(2015).The effect of hemiketals on the relaxivity of endohedral gadofullerenols.RSC ADVANCES,5(117),96253-96257. |
| MLA | Zou, Toujun,et al."The effect of hemiketals on the relaxivity of endohedral gadofullerenols".RSC ADVANCES 5.117(2015):96253-96257. |
入库方式： OAI收割
来源：化学研究所
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