Lineage-specific chromatin signatures reveal a regulator of lipid metabolism in microalgae
文献类型：期刊论文
| 作者 | Ngan, Chew Yee1; Wong, Chee-Hong1; Choi, Cindy1; Yoshinaga, Yuko1; Louie, Katherine1,2; Jia, Jing3,4; Chen, Cindy1; Bowen, Benjamin1,2; Cheng, Haoyu1; Leonelli, Lauriebeth5 |
| 刊名 | NATURE PLANTS
 |
| 出版日期 | 2015-07-27 |
| 卷号 | 1期号:8 |
| 英文摘要 | Alga-derived lipids represent an attractive potential source of biofuels. However, lipid accumulation in algae is a stress response tightly coupled to growth arrest, thereby imposing a major limitation on productivity. To identify transcriptional regulators of lipid accumulation, we performed an integrative chromatin signature and transcriptomic analysis to decipher the regulation of lipid biosynthesis in the alga Chlamydomonas reinhardtii. Genome-wide histone modification profiling revealed remarkable differences in functional chromatin states between the algae and higher eukaryotes and uncovered regulatory components at the core of lipid accumulation pathways. We identified the transcription factor, PSR1, as a pivotal switch that triggers cytosolic lipid accumulation. Dissection of the PSR1-induced lipid profiles corroborates its role in coordinating multiple lipid-inducing stress responses. The comprehensive maps of functional chromatin signatures in a major clade of eukaryotic life and the discovery of a transcriptional regulator of algal lipid metabolism will facilitate targeted engineering strategies to mediate high lipid production in microalgae. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Plant Sciences |
| 研究领域[WOS] | Plant Sciences |
| 关键词[WOS] | CHLAMYDOMONAS-REINHARDTII ; GENOME-WIDE ; TRIACYLGLYCEROL ACCUMULATION ; EPIGENETIC MODIFICATIONS ; DEPRIVATION RESPONSES ; BIODIESEL PRODUCTION ; HISTONE METHYLATION ; BIOFUEL PRODUCTION ; PHOSPHORUS ; ARABIDOPSIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000364380700001 |
| 公开日期 | 2015-12-29 |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/6779]  |
| 专题 | 青岛生物能源与过程研究所_单细胞中心 |
| 作者单位 | 1.US DOE, Joint Genorne Inst, Walnut Creek, CA 94598 USA 2.Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Life Sci, Berkeley, CA 94720 USA 3.Chinese Acad Sci, Qingdao Inst BioEnergy & Bioproc Technol, Single Cell Ctr, CAS Key Lab Biofuels, Qingdao 266101, Shandong, Peoples R China 4.Chinese Acad Sci, Qingdao Inst BioEnergy & Bioproc Technol, Shandong Key Lab Energy Genet, Qingdao 266101, Shandong, Peoples R China 5.Univ Calif Berkeley, Howard Hughes Med Inst, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA 6.Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Genom Div, Berkeley, CA 94720 USA 7.Univ Calif, Sch Nat Sci, Merced, CA 95343 USA 8.Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA 94720 USA |
| 推荐引用方式 GB/T 7714 | Ngan, Chew Yee,Wong, Chee-Hong,Choi, Cindy,et al. Lineage-specific chromatin signatures reveal a regulator of lipid metabolism in microalgae[J]. NATURE PLANTS,2015,1(8). |
| APA | Ngan, Chew Yee.,Wong, Chee-Hong.,Choi, Cindy.,Yoshinaga, Yuko.,Louie, Katherine.,...&Wei, Chia-Lin.(2015).Lineage-specific chromatin signatures reveal a regulator of lipid metabolism in microalgae.NATURE PLANTS,1(8). |
| MLA | Ngan, Chew Yee,et al."Lineage-specific chromatin signatures reveal a regulator of lipid metabolism in microalgae".NATURE PLANTS 1.8(2015). |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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