Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film
文献类型：期刊论文
| 作者 | Hu QL; Jiao B ; Shi XH(施兴华); Valle RP; Zuo YY; Hu GQ(胡国庆)
|
| 刊名 | NANOSCALE
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:43页码:18025-18029 |
| 通讯作者邮箱 | yzuo@hawaii.edu ; guoqing.hu@imech.ac.cn |
| ISSN号 | 2040-3364 |
| 产权排序 | [Hu, Qinglin; Jiao, Bao; Shi, Xinghua; Hu, Guoqing] Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; [Valle, Russell P.; Zuo, Yi Y.] Univ Hawaii Manoa, Dept Mech Engn, Honolulu, HI 96822 USA |
| 通讯作者 | Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China. |
| 中文摘要 | Graphene oxide (GO) is the most common derivative of graphene and has been used in a large range of biomedical applications. Despite considerable progress in understanding its cytotoxicity, its potential inhalation toxicity is still largely unknown. As the pulmonary surfactant (PS) film is the first line of host defense, interaction with the PS film determines the fate of the inhaled nanomaterials and their potential toxicity. Using a coarse-grained molecular dynamics model, we reported, for the first time, a novel mechanism of toxicity caused by the inhaled GO nanosheets. Upon deposition, the GO nanosheets induce pores in the PS film and thus have adverse effects on the ultrastructure and biophysical properties of the PS film. Notably, the pores induced by GO nanosheets result in increasing the compressibility of the PS film, which is an important indication of surfactant inhibition. In vitro experiments have also been conducted to study the interactions between GO and animal-derived natural PS films, qualitatively confirming the simulation results. |
| 分类号 | 一类 |
| 类目[WOS] | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 关键词[WOS] | NANOPARTICLES ; TOXICITY ; TRANSLOCATION ; NANOPLATELETS ; NANOMATERIALS ; CYTOTOXICITY ; SIMULATIONS ; INHIBITION ; MONOLAYER ; SYSTEM |
| 收录类别 | SCI ; EI |
| 原文出处 | http://dx.doi.org/10.1039/c5nr05401j |
| 语种 | 英语 |
| WOS记录号 | WOS:000364048900006 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/58389]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Hu QL,Jiao B,Shi XH,et al. Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film[J]. NANOSCALE,2015,7(43):18025-18029. |
| APA | Hu QL,Jiao B,施兴华,Valle RP,Zuo YY,&胡国庆.(2015).Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film.NANOSCALE,7(43),18025-18029. |
| MLA | Hu QL,et al."Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film".NANOSCALE 7.43(2015):18025-18029. |
入库方式： OAI收割
来源：力学研究所
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