Mechano-biological Coupling of Cellular Responses to Microgravity
文献类型：期刊论文
| 作者 | Long M(龙勉) ; Wang YR(王育人); Zheng HQ; Shang P; Duan EK; Lu DY
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| 刊名 | MICROGRAVITY SCIENCE AND TECHNOLOGY
 |
| 出版日期 | 2015-09 |
| 卷号 | 27期号:6页码:505-514 |
| 通讯作者邮箱 | mlong@imech.ac.cn |
| 关键词 | Microgravity Mechanobiology Mechanotransduction Cells |
| ISSN号 | 0938-0108 |
| 产权排序 | [Long, Mian; Wang, Yuren; Lu, Dongyuan] Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China; [Long, Mian; Lu, Dongyuan] Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China; [Long, Mian; Lu, Dongyuan] Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China; [Zheng, Huiqiong] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Lab Photosynth & Environm Biol, Beijing 100190, Peoples R China; [Shang, Peng] Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Peoples R China; [Duan, Enkui] Chinese Acad Sci, State Key Lab Stem Cell & Reprod Biol, Inst Zool, Beijing 100190, Peoples R China |
| 通讯作者 | Long, M (reprint author), Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, 15 North 4th Ring Rd, Beijing 100190, Peoples R China. |
| 中文摘要 | Cellular response to microgravity is a basic issue in space biological sciences as well as space physiology and medicine. It is crucial to elucidate the mechano-biological coupling mechanisms of various biological organisms, since, from the principle of adaptability, all species evolved on the earth must possess the structure and function that adapts their living environment. As a basic element of an organism, a cell usually undergoes mechanical and chemical remodeling to sense, transmit, transduce, and respond to the alteration of gravitational signals. In the past decades, new computational platforms and experimental methods/techniques/devices are developed to mimic the biological effects of microgravity environment from the viewpoint of biomechanical approaches. Mechanobiology of plant gravisensing in the responses of statolith movements along the gravity vector and the relevant signal transduction and molecular regulatory mechanisms are investigated at gene, transcription, and protein levels. Mechanotransduction of bone or immune cell responses and stem cell development and tissue histogenesis are elucidated under microgravity. In this review, several important issues are briefly discussed. Future issues on gravisensing and mechanotransducing mechanisms are also proposed for ground-based studies as well as space missions. |
| 分类号 | 二类/Q2 |
| 类目[WOS] | Engineering, Aerospace ; Thermodynamics ; Mechanics |
| 研究领域[WOS] | Engineering ; Thermodynamics ; Mechanics |
| 关键词[WOS] | EMBRYONIC STEM-CELLS ; ARABIDOPSIS-THALIANA ; SIMULATED MICROGRAVITY ; AMYLOPLAST DISPLACEMENT ; MAGNETIC-FIELD ; IN-VITRO ; GRAVITROPISM ; DIFFERENTIATION ; GRAVITY ; STRESS |
| 收录类别 | SCI ; EI |
| 原文出处 | http://dx.doi.org/10.1007/s12217-015-9464-7 |
| 语种 | 英语 |
| WOS记录号 | WOS:000366103800012 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/58368]  |
| 专题 | 力学研究所_国家微重力实验室 |
| 推荐引用方式 GB/T 7714 | Long M,Wang YR,Zheng HQ,et al. Mechano-biological Coupling of Cellular Responses to Microgravity[J]. MICROGRAVITY SCIENCE AND TECHNOLOGY,2015,27(6):505-514. |
| APA | 龙勉,王育人,Zheng HQ,Shang P,Duan EK,&Lu DY.(2015).Mechano-biological Coupling of Cellular Responses to Microgravity.MICROGRAVITY SCIENCE AND TECHNOLOGY,27(6),505-514. |
| MLA | 龙勉,et al."Mechano-biological Coupling of Cellular Responses to Microgravity".MICROGRAVITY SCIENCE AND TECHNOLOGY 27.6(2015):505-514. |
入库方式： OAI收割
来源：力学研究所
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