Inferring the hosts of coronavirus using dual statistical models based on nucleotide composition
文献类型：期刊论文
| 作者 | Tang, Qin1,2; Song, Yulong1,2; Shi, Mijuan1; Cheng, Yingyin1; Zhang, Wanting1; Xia, Xiao-Qin1 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015-11-26 |
| 卷号 | 5 |
| ISSN号 | 2045-2322 |
| 英文摘要 | Many coronaviruses are capable of interspecies transmission. Some of them have caused worldwide panic as emerging human pathogens in recent years, e.g., severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). In order to assess their threat to humans, we explored to infer the potential hosts of coronaviruses using a dual-model approach based on nineteen parameters computed from spike genes of coronaviruses. Both the support vector machine (SVM) model and the Mahalanobis distance (MD) discriminant model achieved high accuracies in leave-one-out cross-validation of training data consisting of 730 representative coronaviruses (99.86% and 98.08% respectively). Predictions on 47 additional coronaviruses precisely conformed to conclusions or speculations by other researchers. Our approach is implemented as a web server that can be accessed at http://bioinfo.ihb.ac.cn/seq2hosts. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | RESPIRATORY SYNDROME CORONAVIRUS ; RECEPTOR-BINDING DOMAIN ; INFLUENZA-A VIRUSES ; CODON USAGE ; SARS CORONAVIRUS ; RNA VIRUSES ; PALM CIVET ; SEQUENCE ; GENOMES ; BETACORONAVIRUS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000365390700001 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/27422]  |
| 专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Ctr Mol & Cellular Biol Aquat Organisms, Wuhan 430072, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Qin,Song, Yulong,Shi, Mijuan,et al. Inferring the hosts of coronavirus using dual statistical models based on nucleotide composition[J]. SCIENTIFIC REPORTS,2015,5. |
| APA | Tang, Qin,Song, Yulong,Shi, Mijuan,Cheng, Yingyin,Zhang, Wanting,&Xia, Xiao-Qin.(2015).Inferring the hosts of coronavirus using dual statistical models based on nucleotide composition.SCIENTIFIC REPORTS,5. |
| MLA | Tang, Qin,et al."Inferring the hosts of coronavirus using dual statistical models based on nucleotide composition".SCIENTIFIC REPORTS 5(2015). |
入库方式： OAI收割
来源：水生生物研究所
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