Transcriptomic analysis of the host response to an iridovirus infection in Chinese giant salamander, Andrias davidianus
文献类型：期刊论文
| 作者 | Fan, Yuding1,4; Chang, Ming Xian2; Ma, Jie1; LaPatra, Scott E.3; Hu, Yi Wei2; Huang, Lili1; Nie, Pin2; Zeng, Lingbing1 |
| 刊名 | VETERINARY RESEARCH
 |
| 出版日期 | 2015-11-20 |
| 卷号 | 46 |
| ISSN号 | 0928-4249 |
| 英文摘要 | The emergence of an infectious viral disease caused by the Chinese giant salamander iridovirus (GSIV) has led to substantial economic losses. However, no more molecular information is available for the understanding of the mechanisms associated with virus-host interaction. In this study, de novo sequencing was used to obtain abundant high-quality ESTs and investigate differentially-expressed genes in the spleen of Chinese giant salamanders that were either infected or mock infected with GSIV. Comparative expression analysis indicated that 293 genes were down-regulated and 220 genes were up-regulated. Further enrichment analysis showed that the most enriched pathway is "complement and coagulation cascades", and significantly enriched diseases include "inherited thrombophilia", "immune system diseases", "primary immunodeficiency", "complement regulatory protein defects", and "disorders of nucleotide excision repair". Additionally, 30 678 simple sequence repeats (SSRs) from all spleen samples, 26 355 single nucleotide polymorphisms (SNPs) from the spleens of uninfected animals and 36 070 SNPs from the spleens of infected animals were detected. The large amount of variation was specific for the Chinese giant salamanders that were infected with GSIV. The results reported herein provided significant and new EST information that could contribute greatly in investigations into the molecular functions of immune genes in the Chinese giant salamander. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Veterinary Sciences |
| 研究领域[WOS] | Veterinary Sciences |
| 关键词[WOS] | TOLL-LIKE RECEPTORS ; NOD-LIKE RECEPTORS ; IMMUNE GENE REPERTOIRE ; RNA-SEQ DATA ; INNATE IMMUNITY ; FUNCTIONAL-CHARACTERIZATION ; REFERENCE GENOME ; CHANNEL CATFISH ; SPLICE VARIANTS ; EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000365161200003 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/27399]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Hubei, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China 3.Clear Springs Foods Inc, Div Res, Buhl, ID 83316 USA 4.Huazhong Agr Univ, Freshwater Aquaculture Collaborat Innovat Ctr Hub, Wuhan 430223, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Yuding,Chang, Ming Xian,Ma, Jie,et al. Transcriptomic analysis of the host response to an iridovirus infection in Chinese giant salamander, Andrias davidianus[J]. VETERINARY RESEARCH,2015,46. |
| APA | Fan, Yuding.,Chang, Ming Xian.,Ma, Jie.,LaPatra, Scott E..,Hu, Yi Wei.,...&Zeng, Lingbing.(2015).Transcriptomic analysis of the host response to an iridovirus infection in Chinese giant salamander, Andrias davidianus.VETERINARY RESEARCH,46. |
| MLA | Fan, Yuding,et al."Transcriptomic analysis of the host response to an iridovirus infection in Chinese giant salamander, Andrias davidianus".VETERINARY RESEARCH 46(2015). |
入库方式： OAI收割
来源：水生生物研究所
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