Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice
文献类型：期刊论文
| 作者 | Singh, Vishal1; Chassaing, Benoit2; Zhang, Limin3,4,5,6; Yeoh, Beng San1; Xiao, Xia1; Kumar, Manish1; Baker, Mark T.2; Cai, Jingwei3; Walker, Rachel1; Borkowski, Kamil1 |
| 刊名 | CELL METABOLISM
 |
| 出版日期 | 2015-12-01 |
| 卷号 | 22期号:6页码:983-996 |
| 英文摘要 | The gut microbiota plays a key role in host metabolism. Toll-like receptor 5 (TLR5), a flagellin receptor, is required for gut microbiota homeostasis. Accordingly, TLR5-deficient (T5KO) mice are prone to develop microbiota-dependent metabolic syndrome. Here we observed that T5KO mice display elevated neutral lipids with a compositional increase of oleate [C18:1 (n9)] relative to wild-type littermates. Increased oleate contribution to hepatic lipids and liver SCD1 expression were both microbiota dependent. Analysis of short-chain fatty acids (SCFAs) and C-13-acetate label incorporation revealed elevated SCFA in ceca and hepatic portal blood and increased liver de novo lipogenesis in T5KO mice. Dietary SCFAs further aggravated metabolic syndrome in T5KO mice. Deletion of hepatic SCD1 not only prevented hepatic neutral lipid oleate enrichment but also ameliorated metabolic syndrome in T5KO mice. Collectively, these results underscore the key role of the gut microbiota-liver axis in the pathogenesis of metabolic diseases. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Cell Biology ; Endocrinology & Metabolism |
| 研究领域[WOS] | Cell Biology ; Endocrinology & Metabolism |
| 关键词[WOS] | CHAIN FATTY-ACIDS ; INDUCED INSULIN-RESISTANCE ; DIET-INDUCED OBESITY ; GUT MICROBIOTA ; INFLAMMATORY RESPONSES ; RECEPTOR GPR43 ; HOST ENERGY ; ESTERS ; LIPIDS ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000365993100007 |
| 公开日期 | 2016-01-19 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9080]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA 2.Georgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA 3.Penn State Univ, Dept Vet & Biomed Sci, Ctr Mol Toxicol & Carcinogenesis, University Pk, PA 16802 USA 4.Chinese Acad Sci, Wuhan, Peoples R China 5.State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China 6.Natl Ctr Magnet Resonance, Wuhan, Peoples R China 7.Penn State Univ, Dept Anim Sci, University Pk, PA 16802 USA 8.Georgia Regents Univ, Biochem & Mol Biol, Augusta, GA 30912 USA 9.Univ Wisconsin, Dept Biochem & Nutr Sci, Madison, WI 53706 USA 10.Univ Toledo, Dept Physiol & Pharmacol, Coll Med & Life Sci, Toledo, OH 43614 USA |
| 推荐引用方式 GB/T 7714 | Singh, Vishal,Chassaing, Benoit,Zhang, Limin,et al. Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice[J]. CELL METABOLISM,2015,22(6):983-996. |
| APA | Singh, Vishal.,Chassaing, Benoit.,Zhang, Limin.,Yeoh, Beng San.,Xiao, Xia.,...&Vijay-Kumar, Matam.(2015).Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice.CELL METABOLISM,22(6),983-996. |
| MLA | Singh, Vishal,et al."Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice".CELL METABOLISM 22.6(2015):983-996. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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