Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis
文献类型：期刊论文
| 作者 | CHEN，Zhongcai; CAI，Shang; JIANG，Qing; ZHANG，Chuanmao; Tang，Xiaowei; Tang XW(唐孝威)
|
| 刊名 | 科学通报（英文版）
 |
| 出版日期 | 2005 |
| 期号 | 3页码:229-235 |
| 关键词 | cytokinesis microtubule actin Filament cytochalasin B nocodazole |
| 英文摘要 | Microtubule and microfilament cytoskeletons play key roles in the whole process of cytokinesis. Although a number of hypotheses have been proposed to elucidate the mechanism of cytokinesis by microtubule and actin filament cytoskeletons, many reports are conflicting. In our study, combining the cytoskeletons drug treatments with the time-lapse video technology, we retested the key roles of microtubule and actin filament in cytokinesis. The results showed that depolymerization of microtubules by Nocodazole after the initiation of furrowing would not inhibit the furrow ingression, but obviously decrease the stiffness of daughter cells. Depolymerizing actin filaments by Cytochalasin B before metaphase would inhibit the initiation of furrowing but not chromosome segregation, resulting in the formation of binucleate cells; however, depolymerizing actin filaments during anaphase would prevent furrowing and lead to the regress of established furrow, also resulting in the formation of binucleate cells. Further, depolymerizing microtubules and actin filaments simultaneously after metaphase would cause the quick regress of the furrow and the formation of binucleate cells. From these results we propose that a successful cytokinesis requires functions and coordination of both the microtubule and actin filament cytoskeletons. Microtubule cytoskeleton may function in the positioning and initiation of cleavage furrow, and the actin filament cytoskeleton may play key roles in the initiation and ingression of the furrow. |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/215772]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_粒子天体物理中心 |
| 推荐引用方式 GB/T 7714 | CHEN，Zhongcai,CAI，Shang,JIANG，Qing,et al. Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis[J]. 科学通报（英文版）,2005(3):229-235. |
| APA | CHEN，Zhongcai,CAI，Shang,JIANG，Qing,ZHANG，Chuanmao,Tang，Xiaowei,&唐孝威.(2005).Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis.科学通报（英文版）(3),229-235. |
| MLA | CHEN，Zhongcai,et al."Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis".科学通报（英文版） .3(2005):229-235. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。