The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts
文献类型：期刊论文
| 作者 | Yang N(杨宁); Chen ZC(陈中才); LU，Ping; ZHANG，Chuanmao; ZHAI，Zhonghe; Tang，Xiaowei; Tang XW(唐孝威)
|
| 刊名 | 科学通报(英文版)
 |
| 出版日期 | 2003 |
| 期号 | 18页码:1912-1918 |
| 关键词 | nuclear reassembly microtubule colchicine taxol Xenopus egg extracts |
| 英文摘要 | Nuclear envelope is a dynamic structure in the cell cycle. At the beginning of mitosis, nuclear envelope breaks down and its components disperse into the cytoplasm. At the end of mitosis, nuclear envelope reassembles using the dispersed components. Searching for the mechanisms of the nuclear disassembly and reassembly has for a long time been one of the key projects for cell biologists. In this report we show that microtubules take a role in the nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts. Microtubule cytoskeleton has been demonstrated to take roles in the transport of intracellular membranes such as Golgi and ER vesicles. We found that the nuclear envelope assembly needs functional microtubules. At the beginning of the nuclear assembly, microtubules nucleated to form a microtubule aster around the centrosome at the base of the sperm head. Using the microtubule drug colchicine to disrupt the microtubule nucleation, nuclear envelope reassembly was seriously inhibited. If the microtubules were stabilized by taxol, another microtubule drug, the nuclear envelope reassembly was also interfered, although a significantly large aster formed around the chromatin. Based on these observations, we propose that microtubules play an important role in the nuclear envelope reassembly maybe by transporting the nuclear envelope precursors to the chromatin surfaces. |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/215773]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_粒子天体物理中心 |
| 推荐引用方式 GB/T 7714 | Yang N,Chen ZC,LU，Ping,et al. The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts[J]. 科学通报(英文版),2003(18):1912-1918. |
| APA | 杨宁.,陈中才.,LU，Ping.,ZHANG，Chuanmao.,ZHAI，Zhonghe.,...&唐孝威.(2003).The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts.科学通报(英文版)(18),1912-1918. |
| MLA | 杨宁,et al."The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts".科学通报(英文版) .18(2003):1912-1918. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。