中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones

文献类型:期刊论文

作者Xu, Rui1,2; Xu, Gang-Ming1; Li, Xiao-Ming1; Li, Chun-Shun1; Wang, Bin-Gui1
刊名MARINE DRUGS
出版日期2015-11-01
卷号13期号:11页码:7040-7054
关键词Aspergillus dimorphicus anti-tumor agent wentilactones optimization
英文摘要The potential anti-tumor agent wentilactones were produced by a newly isolated marine fungus Aspergillus dimorphicus. This fungus was derived from deep-sea sediment and identified by polyphasic approach, combining phenotypic, molecular, and extrolite profiles. However, wentilactone production was detected only under static cultures with very low yields. In order to improve wentilactone production, culture conditions were optimized using the response surface methodology. Under the optimal static fermentation conditions, the experimental values were closely consistent with the prediction model. The yields of wentilactone A and B were increased about 11-fold to 13.4 and 6.5 mg/L, respectively. The result was further verified by fermentation scale-up for wentilactone production. Moreover, some small-molecule elicitors were found to have capacity of stimulating wentilactone production. To our knowledge, this is first report of optimized production of tetranorlabdane diterpenoids by a deep-sea derived marine fungus. The present study might be valuable for efficient production of wentilactones and fundamental investigation of the anti-tumor mechanism of norditerpenoids.
收录类别SCI
语种英语
WOS记录号WOS:000365645400025
源URL[http://ir.qdio.ac.cn/handle/337002/86533]  
专题海洋研究所_实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Xu, Rui,Xu, Gang-Ming,Li, Xiao-Ming,et al. Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones[J]. MARINE DRUGS,2015,13(11):7040-7054.
APA Xu, Rui,Xu, Gang-Ming,Li, Xiao-Ming,Li, Chun-Shun,&Wang, Bin-Gui.(2015).Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones.MARINE DRUGS,13(11),7040-7054.
MLA Xu, Rui,et al."Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones".MARINE DRUGS 13.11(2015):7040-7054.

入库方式: OAI收割

来源:海洋研究所

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