The China-Pakistan International Karakorum Highway situates at the penglacial region through the Western Karakorum-Himalaya Mountain ( Trans-Himalaya) . Along the Highway, flourishing glacier activities, such as glacier thaw, glacier advance and retreat, etc. contribute to occurrences of kinds of geological disasters, ruining the Highway and threating transport safety. The KKH reconstruction and extension project is targeted to geohazard prevention and control. Geohazard prevention and mitigation in a scientific approach rely on understanding of the KKH glaciers and related glaciated geohazards about their formation and development. Through field investigation, site observations, literature retrieval and review, remote sensing interpretation and other research approaches, it is found that (1) the KKH is featured by the unique monsoon-effected penglacial landforms, rich summer accumulated snow precipitation at peaks, extremes of precipitous valley relief, valley-localized glacier movements and the shifted contour extreme storms, which produces lots of surge glaciers with distinct behaviours characterized by perennial recession with unexpected surge, asynchronous movements for adjacent glaciers, summer accumulation type and outstanding hanging glacier activity. The glaciers along KKH could be zoned into 4 sections of active glacier group. The group of Pasu Mustaghs, near the Hunza River Valley, is currently the most threatening. The glaciated geohazards along KKH can be divided into 2 categories (glacier hazard and glacier geohazard) with 10 subcategories. Among them, glacial lake outburst, glacial debris flow are challenging most in engineering for prevention and mitigation.