3-Arylcoumarins: Synthesis and potent anti-inflammatory activity
文献类型：期刊论文
| 作者 | Pu, Wenchen ; Lin, Yuan ; Zhang, Jianshuo ; Wang, Fei ; Wang, Chun ; Zhang, Guolin |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2014 |
| 卷号 | 24期号:23页码:5432-5434 |
| 关键词 | Anti-inflammatory activity Nitric oxide production Coumarin Perkin reaction |
| 产权排序 | 1 |
| 通讯作者 | Zhang, GL (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China. |
| 合作状况 | 其它 |
| 英文摘要 | Chronic inflammation is the persistent and excessive immune response and can lead to a variety of diseases. Aiming to discover new compounds with anti-inflammatory activity, we report herein the synthesis and biological evaluation of 3-arylcoumarins. Thirty five 3-arylcoumarins were prepared through Perkin condensation and further acid-promoted hydrolysis if necessary. In lipopolysaccharide-activated mouse macrophage RAW264.7 cells, 6,8-dichloro-3-(2-methoxyphenyl) coumarin (16) and 6-bromo-8-methoxy-3-(3-methoxyphenyl) coumarin (25) exhibited nitric oxide production inhibitory activity with the IC50 values of 8.5 mu M and 6.9 mu M, respectively, providing a pharmacological potential as anti-inflammatory agents. (C) 2014 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Medicinal; Chemistry, Organic |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://210.75.237.14/handle/351003/26659]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Pu, Wenchen,Lin, Yuan,Zhang, Jianshuo,et al. 3-Arylcoumarins: Synthesis and potent anti-inflammatory activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(23):5432-5434. |
| APA | Pu, Wenchen,Lin, Yuan,Zhang, Jianshuo,Wang, Fei,Wang, Chun,&Zhang, Guolin.(2014).3-Arylcoumarins: Synthesis and potent anti-inflammatory activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(23),5432-5434. |
| MLA | Pu, Wenchen,et al."3-Arylcoumarins: Synthesis and potent anti-inflammatory activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.23(2014):5432-5434. |
入库方式： OAI收割
来源：成都生物研究所
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