Umbilical cord blood mesenchymal stem cells co-modified by TERT and BDNF: A novel neuroprotective therapy for neonatal hypoxic-ischemic brain damage
文献类型：期刊论文
| 作者 | Zhao, Fengyan ; Qu, Yi ; Liu, Haiting ; Du, Baowen ; Mu, Dezhi |
| 刊名 | INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
 |
| 出版日期 | 2014 |
| 卷号 | 38期号:2014页码:147-154 |
| 关键词 | Telomerase reverse transcriptase Brain-derived neurotrophic factor Hypoxic-ischemic brain damage Umbilical cord blood mesenchymal stem cells |
| 产权排序 | 4 |
| 通讯作者 | Mu, DZ (reprint author), Sichuan Univ, Dept Pediat, West China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China. |
| 合作状况 | 其它 |
| 英文摘要 | Hypoxic-ischemic brain damage (HIBD), a leading cause of perinatal disability and death, has limited therapeutic options. Stem cell therapy has been demonstrated as a potential novel therapy for neurological disorders. Compared with other types of stem cells, umbilical cord blood mesenchymal stem cells (UCB-MSCs) have several unique characteristics, such as a higher rate of cell proliferation and clonality. However, the limited life span of UCB-MSCs hinders their clinical application. Therefore, efforts are urgently needed to circumvent this disadvantage. Telomerase reverse transcriptase (TERT), which promotes cell proliferation and survival, plays a protective role in hypoxic-ischemic (HI) brain injury. Thus, it is reasonable to propose that UCB-MSCs modified by exogenous TERT expression might have a longer lifespan and increased viability. Moreover, brain-derived neurotrophic factor (BDNF), a neurotrophin that regulates development, regeneration, survival and maintenance of neurons, facilitates post-injury recovery when administered by infusion or virus-mediated delivery. Therefore, TERT- and BDNF-modified UCB-MSCs may have a longer lifespan and also maintain neural differentiation, thus promoting the recovery of neurological function following hypoxic-ischemic brain damage (HIBD) and thereby representing a new effective strategy for HIBD in neonates. (C) 2014 Published by Elsevier Ltd. on behalf of ISDN. |
| 学科主题 | Developmental Biology; Neurosciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://210.75.237.14/handle/351003/26662]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Zhao, Fengyan,Qu, Yi,Liu, Haiting,et al. Umbilical cord blood mesenchymal stem cells co-modified by TERT and BDNF: A novel neuroprotective therapy for neonatal hypoxic-ischemic brain damage[J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,2014,38(2014):147-154. |
| APA | Zhao, Fengyan,Qu, Yi,Liu, Haiting,Du, Baowen,&Mu, Dezhi.(2014).Umbilical cord blood mesenchymal stem cells co-modified by TERT and BDNF: A novel neuroprotective therapy for neonatal hypoxic-ischemic brain damage.INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,38(2014),147-154. |
| MLA | Zhao, Fengyan,et al."Umbilical cord blood mesenchymal stem cells co-modified by TERT and BDNF: A novel neuroprotective therapy for neonatal hypoxic-ischemic brain damage".INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 38.2014(2014):147-154. |
入库方式： OAI收割
来源：成都生物研究所
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