pH-responsive polymer-drug conjugates as multifunctional micelles for cancer-drug delivery
文献类型：期刊论文
| 作者 | Kang, Yang ; Ha, Wei ; Liu, Ying-Qian ; Ma, Yuan ; Fan, Min-Min ; Ding, Li-Sheng ; Zhang, Sheng ; Li, Bang-Jing |
| 刊名 | NANOTECHNOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 25期号:33页码:335101(1-12) |
| 关键词 | micelle anticancer drug carrier podophyllotoxin pH-responsible cleavage |
| 产权排序 | 1 |
| 通讯作者 | Kang, Y (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu 610041, Peoples R China. |
| 合作状况 | 其它 |
| 英文摘要 | We developed a novel linear pH-sensitive conjugate methoxy poly(ethylene glycol)-4 beta-aminopodophyllotoxin (mPEG-NPOD-I) by a covalently linked 4 beta-aminopodophyllotoxin (NPOD) and PEG via imine bond, which was amphiphilic and self-assembled to micelles in an aqueous solution. The mPEG-NPOD-I micelles simultaneously served as an anticancer drug conjugate and as drug carriers. As a drug conjugate, mPEG-NPOD-I showed a significantly faster NPOD release at a mildly acidic pH of 5.0 and 4.0 than a physiological pH of 7.4. Notably, it was confirmed that this drug conjugate could efficiently deliver NPOD to the nuclei of the tumor cells and led to much more cytotoxic effects to A549, Hela, and HepG2 cancer cells than the parent NPOD. The half maximal inhibitory concentration (IC50) of mPEG-NPOD-I was about one order magnitude lower than that of the NPOD. In vivo, mPEG-NPOD-I reduced the size of the tumors significantly, and the biodistribution studies indicated that this drug conjugate could selectively accumulate in tumor tissues. As drug carriers, the mPEG-NPOD-I micelles encapsulated hydrophobic PTX with drug-loading efficiencies of 57% and drug-loading content of 16%. The loaded PTX also showed pH-triggered fast release behavior, and good additive cytotoxicity effect was observed for the PEG-NPOD-I/PTX. We are convinced that these multifunctional drug conjugate micelles have tremendous potential for targeted cancer therapy. |
| 学科主题 | Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://210.75.237.14/handle/351003/26669]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Kang, Yang,Ha, Wei,Liu, Ying-Qian,et al. pH-responsive polymer-drug conjugates as multifunctional micelles for cancer-drug delivery[J]. NANOTECHNOLOGY,2014,25(33):335101(1-12). |
| APA | Kang, Yang.,Ha, Wei.,Liu, Ying-Qian.,Ma, Yuan.,Fan, Min-Min.,...&Li, Bang-Jing.(2014).pH-responsive polymer-drug conjugates as multifunctional micelles for cancer-drug delivery.NANOTECHNOLOGY,25(33),335101(1-12). |
| MLA | Kang, Yang,et al."pH-responsive polymer-drug conjugates as multifunctional micelles for cancer-drug delivery".NANOTECHNOLOGY 25.33(2014):335101(1-12). |
入库方式： OAI收割
来源：成都生物研究所
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