Nitrogen-Containing Dihydro-beta-agarofuran Derivatives from Tripterygium wilfordii
文献类型：期刊论文
| 作者 | Luo, Yinggang ; Pu, Xiang ; Luo, Guoyong ; Zhou, Min ; Ye, Qi ; Liu, Yan ; Gu, Jian ; Qi, Huayi ; Li, Guoyou ; Zhang, Guolin |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2014 |
| 卷号 | 77期号:7页码:1650-1657 |
| 产权排序 | 1 |
| 通讯作者 | Luo, YG (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Ctr Nat Prod Res, 9 Sect 4,Renmin Rd South, Chengdu 610041, Peoples R China. |
| 合作状况 | 其它 |
| 英文摘要 | Thunder god vine, the dried roots of Tripterygium wilfordii, is a widely used traditional Chinese medicine. More than 200 bioactive complex natural products have been isolated from this herb. Inspired by the diversity of chemical structures and bioactivities of the components of this herb, the investigation to mine new chemical entities as potential drug leads led to the identification of 36 nitrogen-containing compounds. Among them, 18 new dihydro-beta-agarofuran alkaloids (tripterygiumines A-L (1-12), M-Q (22-26), and R (33)) were identified from the spectroscopic data and chemical degradation studies. Tripterygiumine Q (26) exhibited immunosuppressive activity against human peripheral mononuclear cells with an IC50 value of 8.67 mu M and showed no cytotoxicity, even at 100 mu M, indicating that 26 may represent a novel scaffold for the development of new immunosuppressants. |
| 学科主题 | Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://210.75.237.14/handle/351003/26676]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Luo, Yinggang,Pu, Xiang,Luo, Guoyong,et al. Nitrogen-Containing Dihydro-beta-agarofuran Derivatives from Tripterygium wilfordii[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(7):1650-1657. |
| APA | Luo, Yinggang.,Pu, Xiang.,Luo, Guoyong.,Zhou, Min.,Ye, Qi.,...&Zhang, Guolin.(2014).Nitrogen-Containing Dihydro-beta-agarofuran Derivatives from Tripterygium wilfordii.JOURNAL OF NATURAL PRODUCTS,77(7),1650-1657. |
| MLA | Luo, Yinggang,et al."Nitrogen-Containing Dihydro-beta-agarofuran Derivatives from Tripterygium wilfordii".JOURNAL OF NATURAL PRODUCTS 77.7(2014):1650-1657. |
入库方式： OAI收割
来源：成都生物研究所
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