Isolation and Characterization of New Phenolic Compounds with Estrogen Biosynthesis-Inhibiting and Antioxidation Activities from Broussonetia papyrifera Leaves
文献类型：期刊论文
| 作者 | Yang, Chunyan ; Li, Fu ; Du, Baowen ; Chen, Bin ; Wang, Fei ; Wang, Mingkui |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2014 |
| 卷号 | 9期号:4页码:e94198（1-13） |
| 产权排序 | 1 |
| 通讯作者 | Wang, F (reprint author), Chinese Acad Sci, Key Lab Mt Ecol Restorat & Bioresource Utilizat &, Chengdu, Peoples R China. |
| 合作状况 | 其它 |
| 英文摘要 | Broussonetia papyrifera leaves (BPL) as a traditional Chinese medicine are also used in livestock feed for stimulating reproduction, adipose tissue and muscle development; however, the mechanism of their action is still unknown. Through estrogen biosynthesis-guided fractionation in human ovarian granulosa-like KGN cells, five new phenolic glycosides, broussoside A-E(1-5), along with fifteen known dietary phenolic compounds, were isolated from the n-butanol extract of BPL, and their structures were elucidated on the basis of NMR spectra analysis and chemical evidence. New compounds 3, 4, 5 and the known compounds 9 and 10 were found to potently inhibit estrogen biosynthesis in KGN cells. In addition, compounds 9, 17, 18, and 20 showed strong antioxidant activity against ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6sulfonic acid) diammonium salt) and DPPH (1, 1'-diphenyl-2-picryl-hydrazyl radical) assays. These findings suggest that BPL may improve meat quality through the regulation of estrogen biosynthesis. Furthermore, they may be useful for the discovery of potential aromatase modulators from natural products. Finally, they could be considered as a new source for natural antioxidants. |
| 学科主题 | Multidisciplinary Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://210.75.237.14/handle/351003/26688]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Yang, Chunyan,Li, Fu,Du, Baowen,et al. Isolation and Characterization of New Phenolic Compounds with Estrogen Biosynthesis-Inhibiting and Antioxidation Activities from Broussonetia papyrifera Leaves[J]. PLOS ONE,2014,9(4):e94198（1-13）. |
| APA | Yang, Chunyan,Li, Fu,Du, Baowen,Chen, Bin,Wang, Fei,&Wang, Mingkui.(2014).Isolation and Characterization of New Phenolic Compounds with Estrogen Biosynthesis-Inhibiting and Antioxidation Activities from Broussonetia papyrifera Leaves.PLOS ONE,9(4),e94198（1-13）. |
| MLA | Yang, Chunyan,et al."Isolation and Characterization of New Phenolic Compounds with Estrogen Biosynthesis-Inhibiting and Antioxidation Activities from Broussonetia papyrifera Leaves".PLOS ONE 9.4(2014):e94198（1-13）. |
入库方式： OAI收割
来源：成都生物研究所
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