Enantioselective Michael Addition of a-Substituted Cyanoacetates to VinylKetones Catalyzed by Bifunctional Organocatalysts
文献类型：期刊论文
| 作者 | Tian-YuLi ; Rui Li ; Qian Chai ; Jun Long ; Bang-Jing Li ; Yong Wu Li-Sheng Ding,[b] and Ying-Chun Chen*[ |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2007 |
| 卷号 | 13期号:1页码:319-327 |
| 关键词 | amino acids asymmetric organocatalysis cyanoacetate Michael addition thiourea |
| 产权排序 | 2 |
| 通讯作者 | Ying-Chun Chen |
| 合作状况 | 其它 |
| 中文摘要 | A highly enantioselective Michael addition of a-substituted cyanoacetates to vinyl ketones was accomplished in the presence of simple bifunctional thiourea/tertiary amine organocatalysts. A number of a-aryl or alkyl cyanoacetates have been successfully applied to give multifunctional compounds with an all-carbon-substituted quaternary stereocenter in excellent enantioselectivities (82–97% ee) and yields (61–99%). The optical pure adducts could be smoothly converted to variously structured b2,2-amino acid esters. Moreover, an interesting reaction model involving multiple hydrogen- bonding interactions amongst the thiourea/tertiary amine catalyst and the reactants has been proposed based on the absolute configuration of the adduct and computational studies. |
| 学科主题 | 天然产物研究 |
| 收录类别 | 其他 |
| 语种 | 英语 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://210.75.237.14/handle/351003/26765]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Tian-YuLi,Rui Li,Qian Chai,et al. Enantioselective Michael Addition of a-Substituted Cyanoacetates to VinylKetones Catalyzed by Bifunctional Organocatalysts[J]. CHEMISTRY-A EUROPEAN JOURNAL,2007,13(1):319-327. |
| APA | Tian-YuLi,Rui Li,Qian Chai,Jun Long,Bang-Jing Li,&Yong Wu Li-Sheng Ding,[b] and Ying-Chun Chen*[.(2007).Enantioselective Michael Addition of a-Substituted Cyanoacetates to VinylKetones Catalyzed by Bifunctional Organocatalysts.CHEMISTRY-A EUROPEAN JOURNAL,13(1),319-327. |
| MLA | Tian-YuLi,et al."Enantioselective Michael Addition of a-Substituted Cyanoacetates to VinylKetones Catalyzed by Bifunctional Organocatalysts".CHEMISTRY-A EUROPEAN JOURNAL 13.1(2007):319-327. |
入库方式： OAI收割
来源：成都生物研究所
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