A Triterpene Glycoside from Black Cohosh that Inhibits Osteoclastogenesis by Modulating RANKL and TNFα Signaling Pathways
文献类型：期刊论文
| 作者 | Samuel X. Qiu ; Chun Dan ; Li-Sheng Ding ; Shulin Peng ; Shao-Nong Chen ; Norman R. Farnsworth ; Jan Nolta ; Michael L. Gross ; Ping Zhou |
| 刊名 | Chemistry & Biology
 |
| 出版日期 | 2007 |
| 卷号 | 14期号:7页码:860-869 |
| 关键词 | CHEMBIOL SIGNALING |
| 产权排序 | 2 |
| 通讯作者 | Ping Zhou |
| 合作状况 | 其它 |
| 中文摘要 | Osteoporosis is a major age-related source of morbidity and mortality. Increased bone resorption mediated by osteoclasts is central to its pathogenesis. Cytokines, particularly RANKL and TNFα, are often increased under pathologic conditions, leading to enhanced osteoclastogenesis. Black cohosh (Actaea/Cimicifuga racemosa L), a popular herbal supplement for the treatment of menopausal symptoms, was recently shown to have the beneficial effect of preventing bone loss. Here, we demonstrate that 25-acetylcimigenol xylopyranoside (ACCX), a triterpenoid glycoside isolated from black cohosh, potently blocks in vitro osteoclastogenesis induced by either RANKL or TNFα. This blockage of osteoclastogenesis elicited by ACCX results from abrogation of the NF-κB and ERK pathways induced by either RANKL or TNFα, respectively. Importantly, this compound attenuates TNFα-induced bone loss in vivo. Therefore, ACCX represents a potential lead for the development of a new class of antiosteoporosis agents. |
| 学科主题 | 天然产物研究 |
| 收录类别 | 其他 |
| 语种 | 英语 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://210.75.237.14/handle/351003/26766]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Samuel X. Qiu,Chun Dan,Li-Sheng Ding,et al. A Triterpene Glycoside from Black Cohosh that Inhibits Osteoclastogenesis by Modulating RANKL and TNFα Signaling Pathways[J]. Chemistry & Biology,2007,14(7):860-869. |
| APA | Samuel X. Qiu.,Chun Dan.,Li-Sheng Ding.,Shulin Peng.,Shao-Nong Chen.,...&Ping Zhou.(2007).A Triterpene Glycoside from Black Cohosh that Inhibits Osteoclastogenesis by Modulating RANKL and TNFα Signaling Pathways.Chemistry & Biology,14(7),860-869. |
| MLA | Samuel X. Qiu,et al."A Triterpene Glycoside from Black Cohosh that Inhibits Osteoclastogenesis by Modulating RANKL and TNFα Signaling Pathways".Chemistry & Biology 14.7(2007):860-869. |
入库方式： OAI收割
来源：成都生物研究所
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