Gavage of D-Ribose induces A beta-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice
文献类型：期刊论文
| 作者 | Wu, Beibei1,4; Wei, Yan1; Wang, Yujing1,4; Su, Tao1; Zhou, Lei5; Liu, Ying1 ; He, Rongqiao1,2,3
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| 刊名 | ONCOTARGET
 |
| 出版日期 | 2015-10-27 |
| 卷号 | 6期号:33页码:34128-34142 |
| 关键词 | D-Ribose memory impairment Tau hyperphosphorylation A beta-like deposition anxiety-like behavior Gerotarget |
| ISSN号 | 1949-2553 |
| 英文摘要 | In addition to D-Glucose, D-Ribose is also abnormally elevated in the urine of type 2 diabetic patients, establishing a positive correlation between the concentration of uric D-Ribose and the severity of diabetes. Intraperitoneal injection of D-Ribose causes memory loss and brain inflammation in mice. To simulate a chronic progression of age-related cognitive impairment, we orally administered D-Ribose by gavage at both a low and high dose to 8 week-old male C57BL/6J mice daily for a total of 6 months, followed by behavioral, histological and biochemical analysis. We found that long-term oral administration of D-Ribose impairs spatial learning and memory, accompanied by anxiety-like behavior. Tau was hyperphosphorylated at AT8, S396, S214 and T181 in the brain. A beta-like deposition was also found in the hippocampus for the high dose group. D-Glucose-gavaged mice did not show significant memory loss and anxiety-like behavior under the same experimental conditions. These results demonstrate that a long-term oral administration of D-Ribose not only induces memory loss with anxiety-like behavior, but also elevates A beta-like deposition and Tau hyperphosphorylation, presenting D-Ribose-gavaged mouse as a model for agerelated cognitive impairment and diabetic encephalopathy. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Oncology ; Cell Biology |
| 研究领域[WOS] | Oncology ; Cell Biology |
| 关键词[WOS] | AMYLOID PRECURSOR PROTEIN ; GLYCATION END-PRODUCTS ; TYPE-2 DIABETES-MELLITUS ; ALZHEIMERS-DISEASE ; COGNITIVE IMPAIRMENT ; PHOSPHORYLATED-TAU ; INBRED MICE ; INSULIN ; NEURONS ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000366107200021 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/15391]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Biophys, Ctr Expt Anim, Core Facil Prot Res, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Beibei,Wei, Yan,Wang, Yujing,et al. Gavage of D-Ribose induces A beta-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice[J]. ONCOTARGET,2015,6(33):34128-34142. |
| APA | Wu, Beibei.,Wei, Yan.,Wang, Yujing.,Su, Tao.,Zhou, Lei.,...&He, Rongqiao.(2015).Gavage of D-Ribose induces A beta-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice.ONCOTARGET,6(33),34128-34142. |
| MLA | Wu, Beibei,et al."Gavage of D-Ribose induces A beta-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice".ONCOTARGET 6.33(2015):34128-34142. |
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来源：心理研究所
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