Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats
文献类型：期刊论文
| 作者 | Wang, T.1 ; Hu, X.1; Liang, S.1; Li, W.1; Wu, X.1; Wang, L.2; Jin, F.1
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| 刊名 | BENEFICIAL MICROBES
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:5页码:707-717 |
| 关键词 | gut microbiota probiotic inflammation behaviour hypothalamic-pituitary-adrenal axis |
| ISSN号 | 1876-2883 |
| 英文摘要 | Gut microbiota play a vital role in maintaining the health of the host. Many factors affect gut microbiota; application of broad range antibiotics disturb microbiota, while probiotic application protects the microbiota. To investigate how probiotics alter the physiological and psychological changes induced by antibiotics, we tested the performance of ampicillin-treated rats in the presence or absence of Lactobacillus fermentum strain NS9, in elevated plus maze and Morris water maze. The results showed that NS9 normalised the composition of gut microbiota and alleviated the ampicillin-induced inflammation in the colon. The levels of the mineralocorticoid and N-methyl-D-aspartate receptors were also elevated in the hippocampus of the ampillicin+ NS9 treated group. NS9 administration also reduced the anxiety-like behaviour and alleviated the ampicillin-induced impairment in memory retention. These findings suggest that NS9 is beneficial to the host, because it restores the physiological and psychological abnormalities induced by ampicillin. Our results highlight how gut contents regulate the brain, and shed light on the clinical applications of probiotics to treat the side effect of antibiotics and mental disorders. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Microbiology ; Nutrition & Dietetics |
| 研究领域[WOS] | Microbiology ; Nutrition & Dietetics |
| 关键词[WOS] | REAL-TIME PCR ; INTESTINAL MICROBIOTA ; GUT MICROBIOTA ; MATERNAL SEPARATION ; LIPID-METABOLISM ; GENE-EXPRESSION ; SPATIAL MEMORY ; BRAIN ; BEHAVIOR ; MICE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000367306800011 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/15433]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Hangzhou Normal Univ, Inst Ageing Res, Hangzhou 311121, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, T.,Hu, X.,Liang, S.,et al. Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats[J]. BENEFICIAL MICROBES,2015,6(5):707-717. |
| APA | Wang, T..,Hu, X..,Liang, S..,Li, W..,Wu, X..,...&Jin, F..(2015).Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats.BENEFICIAL MICROBES,6(5),707-717. |
| MLA | Wang, T.,et al."Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats".BENEFICIAL MICROBES 6.5(2015):707-717. |
入库方式： OAI收割
来源：心理研究所
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