Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese
文献类型：期刊论文
| 作者 | Fang, Kechi ; Zhang, Kunlin; Wang, Jing
|
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015-12-21 |
| 卷号 | 5 |
| ISSN号 | 2045-2322 |
| 英文摘要 | Primary Sjogren's syndrome (pSS) is a complex autoimmune disorder. So far, genetic research in pSS has lagged far behind and the underlying biological mechanism is unclear. Further exploring existing genome-wide association study (GWAS) data is urgently expected to uncover disease-related gene combination patterns. Herein, we conducted a network-based analysis by integrating pSS GWAS in Han Chinese with a protein-protein interactions network to identify pSS candidate genes. After module detection and evaluation, 8 dense modules covering 40 genes were obtained for further functional annotation. Additional 31 MHC genes with significant gene-level P-values (sigMHC-gene) were also remained. The combined module genes and sigMHC-genes, a total of 71 genes, were denoted as pSS candidate genes. Of these pSS candidates, 14 genes had been reported to be associated with any of pSS, RA, and SLE, including STAT4, GTF2I, HLA-DPB1, HLA-DRB1, PTTG1, HLA-DQB1, MBL2, TAP2, CFLAR, NFKBIE, HLA-DRA, APOM, HLA-DQA2 and NOTCH4. This is the first report of the network-assisted analysis for pSS GWAS data to explore combined gene patterns associated with pSS. Our study suggests that network-assisted analysis is a useful approach to gaining further insights into the biology of associated genes and providing important clues for future research into pSS etiology. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | GENOME-WIDE ASSOCIATION ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; PROTEIN-INTERACTION NETWORKS ; RHEUMATOID-ARTHRITIS ; KAPPA-B ; IDENTIFIES 9 ; CLASS-II ; GENE ; SUSCEPTIBILITY ; LOCI |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000367076000001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/15437]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Kechi,Zhang, Kunlin,Wang, Jing. Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese[J]. SCIENTIFIC REPORTS,2015,5. |
| APA | Fang, Kechi,Zhang, Kunlin,&Wang, Jing.(2015).Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese.SCIENTIFIC REPORTS,5. |
| MLA | Fang, Kechi,et al."Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese".SCIENTIFIC REPORTS 5(2015). |
入库方式： OAI收割
来源：心理研究所
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