Six new cytotoxic and anti-inflammatory 11, 20-epoxy-ent-kaurane diterpenoids from Isodon wikstroemioides
文献类型：期刊论文
| 作者 | Wu, H. Y.; Wang, W. G.; Du, X.; Yang, J. ; Sun, H. D.
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| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2015 |
| 卷号 | 13期号:5页码:383-389 |
| 关键词 | Isodon wikstroemioides Isowikstroemins H-M Cytotoxicity Anti-inflammatory activity |
| 英文摘要 | The present study was designed to determine the chemical constituents of EtOAc extracts of the aerial parts of Isodon wikstroemioides. Compounds 1-8 were isolated and purified by normal-phase silica gel and reversed-phase C-18 silica gel column chromatography and HPLC. Their structures were elucidated by extensive spectroscopic methods. Most of them were evaluated for their in vitro cytotoxicity against human cancer HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cells and their inhibitory activity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages. Among the eight 11, 20-epoxy-ent-kauranoids isolated, compounds 1-6 (isowikstroemins H-M) were new diterpenoids. Compounds 1, 3, and 7 exhibited significant cytotoxicity with IC50 values ranging from (0.84 +/- 0.02) to (4.09 +/- 0.34) mu mol.L-1, while compounds 4 and 5 showed selective cytotoxicity. In addition, compounds 1, 3, 4, and 7 exhibited inhibitory activity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages. These results provide a basis for future development of these compounds as anti-cancer and anti-inflammatory agents. |
| 类目[WOS] | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 关键词[WOS] | ENT-KAURANE DITERPENOIDS ; C-H ; RUBESCENS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000366435000007 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25073]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wu, H. Y.,Wang, W. G.,Du, X.,et al. Six new cytotoxic and anti-inflammatory 11, 20-epoxy-ent-kaurane diterpenoids from Isodon wikstroemioides[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2015,13(5):383-389. |
| APA | Wu, H. Y.,Wang, W. G.,Du, X.,Yang, J.,&Sun, H. D..(2015).Six new cytotoxic and anti-inflammatory 11, 20-epoxy-ent-kaurane diterpenoids from Isodon wikstroemioides.CHINESE JOURNAL OF NATURAL MEDICINES,13(5),383-389. |
| MLA | Wu, H. Y.,et al."Six new cytotoxic and anti-inflammatory 11, 20-epoxy-ent-kaurane diterpenoids from Isodon wikstroemioides".CHINESE JOURNAL OF NATURAL MEDICINES 13.5(2015):383-389. |
入库方式： OAI收割
来源：昆明植物研究所
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