Design, Synthesis and Cytotoxic Activity of Novel Hybrid Compounds between Aza-brazilin and Imidazolium
文献类型：期刊论文
| 作者 | Wang Xuequan; Li Yan ; Yang Xiaodong; Zhang Hongbin
|
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 35期号:6页码:1276-1285 |
| 关键词 | aza-brazilin imidazole hybrid compound cytotoxic activity |
| 英文摘要 | A series of novel hybrid compounds between aza-brazilin and imidazole have been prepared from 3-(3,4-dimeth-oxyphenyl)propanoic acid. Their structures were confirmed by H-1 NMR, C-13 NMR, HR-ESI-MS and X-ray crystallographic analysis. These compounds have been evaluated in vitro against a panel of human tumor cell lines. 2-Methyl-3-(naphthalen-2-ylmethyl)-1-(2-oxo-2-(4,9,10-trimethoxy-6,6a,7,11b-tetrahydro-5H-indeno [2,1-c] quinolin-5-yl)ethyl)-1H-benzo [d]imidazol-3-ium bromide (26) was found to be the most potent derivative against four strains human tumor lines and more active than cisplatin, and exhibited the most potent cytotoxic activities selectively against HL-60, MCF-7 and SW-480. |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | SAPPAN ; SALTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000359274400009 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25090]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang Xuequan,Li Yan,Yang Xiaodong,et al. Design, Synthesis and Cytotoxic Activity of Novel Hybrid Compounds between Aza-brazilin and Imidazolium[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2015,35(6):1276-1285. |
| APA | Wang Xuequan,Li Yan,Yang Xiaodong,&Zhang Hongbin.(2015).Design, Synthesis and Cytotoxic Activity of Novel Hybrid Compounds between Aza-brazilin and Imidazolium.CHINESE JOURNAL OF ORGANIC CHEMISTRY,35(6),1276-1285. |
| MLA | Wang Xuequan,et al."Design, Synthesis and Cytotoxic Activity of Novel Hybrid Compounds between Aza-brazilin and Imidazolium".CHINESE JOURNAL OF ORGANIC CHEMISTRY 35.6(2015):1276-1285. |
入库方式： OAI收割
来源：昆明植物研究所
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